Registration Dossier
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EC number: 213-999-5 | CAS number: 1071-93-8
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Two key studies with two methods for detecting ready biodegradability are available.
# OECD Guideline 301 E (Modified OECD Screening Test): Biodegradation was 62.1 % by day 28
# OECD Guideline 301 F (Manometric Respirometry Test): Biodegradation was 61 % by day 28. Adipic acid dihydrazide reached the pass level after 28 d but failed the 10-day-window criterion.
Adipic acid dihydrazide is therefore considered to be readily biodegradable, although failing the 10-day window.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable but failing 10-day window
Additional information
Two key studies with two methods for detecting ready biodegradability are available. Their results are in good agreement and demonstrate that adipic acid dihydrazide can be considered as "readily biodegradable".
# OECD Guideline 301 E (Modified OECD Screening Test): The mean biodegradation of the test substance was 62.1 % after 28 days and was just not reaching the pass level of 70 % for "ready biodegradability" within the 10-d window and the 28 d period. Adipic acid dihydrazide was therefore not readily biodegradable in this test.
# OECD Guideline 301 F (Manometric Respirometry Test): Adipic acid dihydrazide was not considered to be readily biodegradable under the conditions of this test. However as biodegradation had achieved 61 %, i.e. > 60 %, by day 28, but failed the 10-day window, adipic acid dihydrazide is considered to be ultimately biodegradable under the condition of this test.
A third source, found in the Japanese NITE database, is based on a OECD 301C MITI-I-test. Result BOD = 1 %, TOC = 3 % after 4 weeks and direct determination by HPLC = 0 %. Accordingly the substance is classified as "not ready biodegradable". This result of the poorly described test does not match the results of the 2 key studies and is therefore disregarded.
Overall, the result of the OECD 301F test demonstrates ready biodegradability and outweighs the 301E study.
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