Registration Dossier
Registration Dossier
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EC number: 220-713-2 | CAS number: 2873-97-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1990
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Very short description of the test, which is a by-product of an investigation on neurotoxicity of acrylamide derivatives.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 981
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The acute oral toxicity of acrylamide and derivatives, including diacetone acrylamide, in mice was determined using 4 animals per dose level and 4 different doses.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- diacetone acrylamide
- IUPAC Name:
- diacetone acrylamide
- Details on test material:
- Supplier: Tokyo Kasei Co.
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: ddY
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Age at study initiation: 5 - 6 weeks old- Weight at study initiation: 29 +- 2.2 g body weight- Housing: 5 - 7 animals per cage- Diet: laboratory chow, ad libitum- Water: ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- physiological saline
- Doses:
- 4 doses.
- No. of animals per sex per dose:
- 4
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 7.7 other: mmol/kg
- 95% CL:
- 6 - 10
- Remarks on result:
- other: The LD50, transferred to usual units, is 1303 mg/kg bw.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- The LD50 of diacetone acrylamide to male mice at oral dosing is 1302 mg/kg body weight.
- Executive summary:
The LD50 was determined as a by-product of an investigation on neurotoxicity of acrylamide derivatives. The LD50 of diacetone acrylamide to male mice at oral dosing is 1303 mg/kg body weight.
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