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EC number: 220-237-5 | CAS number: 2680-03-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 30 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Additional information
In a GLP compliant reproduction/developmental toxicity screening test according to OECD 421, N,N-dimethylacrylamide was given to rats by oral gavage (BASF SE 2013). Initially, groups of 10 male and 10 female Wistar rats (F0 animals) received the test substance, as a solution in (drinking) water, at dose levels of 5, 15 and 45 mg/kg bw/. Because all animals given 45 mg/kg/day lost weight during the first study week, the dose was reduced from 45 to 30 mg/kg bw/day from study day 7 onwards. Rats of the control group received the vehicle, water, alone. The duration of treatment covered a 2-week pre-mating and mating period for both sexes and the entire gestation period as well as 4 days of lactation in female animals followed by an additional treatment until one day before sacrifice (total length of treatment period: males 29 days, females 50 days). Accuracy, homogeneity and stability of formulations were demonstrated by analyses. The daily clinical observations revealed treatment-related signs of toxicity in all males and females at 45/30 mg/kg/day (poor general condition, closed eyelids, piloerection and reduced attention after dosing at the beginning of the pre-mating phase). Food consumption was significantly reduced at 45/30 mg/kg/day in males (pre-mating period) and females (premating period and first week of gestation). During the pre-mating period, growth was retarded in males at 45/30 mg/kg/day and, dose-dependently, in females at 15 and 45/30 mg/kg/day. Mean body weights of these animals remained lower compared to controls until the end of the study (mean terminal body weights were decreased by about 10%). The absolute weights of the testes and epididymides were not affected by treatment. Necropsy and histopathological examination (of the testes, epididymides and ovaries) revealed no treatment-related changes. Male and female mating and fertility indices, pre-coital time, duration of gestation, gestation index, post-implantation loss, litter size, live birth index, pup viability and sex ratio were not affected by treatment. Clinical observations and necropsy of pups revealed no substance-related changes either. Pup weights were decreased at 15 mg/kg bw/day (on PND 1 and 4) and above (PND 1). These lower pup weights were considered to be secondary to the reduced body weight of the dams in these groups. Under the conditions of this Reproduction/Developmental Toxicity Screening Test the oral administration by gavage of N,N-dimethylacrylamide to male and female Wistar rats revealed signs of systemic toxicity at dose levels of 15 mg/kg bw/day (reduced body weight) and above (reduced body weight and clinical signs). Thus, the no observed adverse effect level (NOAEL) for general systemic toxicity was 5 mg/kg bw/day for male and female animals. The NOAEL for reproductive performance, fertility and developmental toxicity was 30 mg/kg bw/day.
Short description of key information:
In a GLP compliant, OECD 421, reproduction/developmental toxicity screening test in rats the highest dose tested, 30 mg/kg bw/day (by oral gavage), was a NOAEL for reproductive performance, fertility and developmental toxicity. The lowest dose tested, 5 mg/kg bw/day, was a NOAEL for general systemic toxicity in the parents.
Effects on developmental toxicity
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
Justification for classification or non-classification
Based on the available data, the test substance does not need to be classified for reproduction toxicity according to the Directive 67/548/EEC and according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Awaiting the developmental study according to OECD 414.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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