Registration Dossier
Registration Dossier
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EC number: 220-237-5 | CAS number: 2680-03-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Near-guideline study, available as published report, no restrictions, fully adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- N,N-dimethylacrylamide
- EC Number:
- 220-237-5
- EC Name:
- N,N-dimethylacrylamide
- Cas Number:
- 2680-03-7
- Molecular formula:
- C5H9NO
- IUPAC Name:
- N,N-dimethylacrylamide
- Details on test material:
- - Name of test material (as cited in study report): N,N-dimethylacrylamide
- Purity: >98.5%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- Not specified
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: shaved intact and abraded skin
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 2 x 0.5 mL (on intact and abraded skin) - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 72 hours
- Number of animals:
- 6
- Details on study design:
- The sample was placed on a small square of cotton gauze and maintained in contact with the skin under a larger square of polyethylene film and anchored to the skin with strips of adhesive tape. A square of flannel cloth was then taped around the trunk of the animal to further protect the patched from being dislodged.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- intact and abraded skin
- Basis:
- mean
- Time point:
- other: 24, 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Remarks:
- intact and abraded skin
- Basis:
- mean
- Time point:
- other: 24, 72 h
- Score:
- 0
- Max. score:
- 4
- Other effects:
- The application of 1 mL total volume caused mortality.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
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