Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 209-798-7 | CAS number: 593-56-6
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- carcinogenicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Does not meet important criteria of today standard methods.
- Reason / purpose for cross-reference:
- reference to same study
- Species:
- mouse
- Strain:
- Swiss Webster
- Sex:
- male
- Route of administration:
- oral: drinking water
- Duration of treatment / exposure:
- 12 weeks
- Frequency of treatment:
- daily
- Post exposure period:
- 40 weeks
- Dose / conc.:
- 6 681.6 mg/L drinking water
- Remarks:
- 80 mM
- No. of animals per sex per dose:
- 3-11
- Control animals:
- yes
- Body weight and weight changes:
- effects observed, treatment-related
- Description (incidence and severity):
- The body weight was depressed
- Haematological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- Increased white blood cell count
- Gross pathological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- Increased spleen size
- Histopathological findings: neoplastic:
- no effects observed
- Executive summary:
Mice were treated for 12 weeks with 6681.6 mg of the substance/l drinking water. After an observation period of further 40 weeks they did not show a higher tumor incidence than the controls.
The test item depressed the body weight and increased the size of the spleen and the white blood cell count. Interestingly, the mice on methoxyammonium chloride appeared to be in better condition than the controls. Mice which drank methoxyammonium chloride solution had no tumors.
Thus, its long-term administration did not cause tumor formation.
Data source
Reference
- Reference Type:
- publication
- Title:
- Chronic administration of hydroxylamine and derivatives in mice.
- Author:
- Yamamoto RS, Weisburger EK, Korzis J.
- Year:
- 1 967
- Bibliographic source:
- Proc Soc Exp Biol Med. 1967 Apr;124(4):1217-20
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- Methoxyammonium chloride
- EC Number:
- 209-798-7
- EC Name:
- Methoxyammonium chloride
- Cas Number:
- 593-56-6
- Molecular formula:
- CH5NO.ClH
- IUPAC Name:
- methoxyammonium chloride
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss Webster
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: drinking water
- Duration of treatment / exposure:
- 12 weeks
- Frequency of treatment:
- daily
Doses / concentrations
- Dose / conc.:
- 6 681.6 mg/L drinking water
- Remarks:
- 80 mM
- No. of animals per sex per dose:
- 3-11
- Control animals:
- yes
Results and discussion
Results of examinations
- Description (incidence and severity):
- Depressed body weights
- Haematological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- Increased white blood cell count
- Gross pathological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- Increased spleen size
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Mice received 6681.6 mg/L drinking water of the substance for 12 weeks and were observed for further 40 weeks. Methoxyamine hydrochloride depressed their body weight and increased the size of the spleen and the white blood cell count. Interestingly, the mice on methoxyamine hydrochloride appeared to be in better condition than the controls and developed no tumors.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
