Registration Dossier
Registration Dossier
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EC number: 222-598-4 | CAS number: 3547-33-9
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary source.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Full Public Report Ethyl Octyl Sulphide
- Author:
- National Industrial Chemicals Notification and Assessment Scheme
- Year:
- 1 998
- Bibliographic source:
- NA/487
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 966
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- other: volunteers as well as nursing home inmates
Test guideline
- Deviations:
- not specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- MGK Repellent 874
- IUPAC Name:
- MGK Repellent 874
- Details on test material:
- - Name of test material (as cited in study report): MGK Repellent 874
- Lot/batch No.: 24
- Formula No. LB-490-66
- Vehicle: Isopropanol
- Concentration: 6%
Constituent 1
Method
- Type of population:
- general
- Ethical approval:
- not specified
- Subjects:
- - Number of subjects exposed: Group A
- Sex: No data
- Age: 20 months to 55 years
- Race: No data
- Demographic information: No data
- Number of subjects exposed: Group B
- Sex: No data
- Age: 30 to `well above' 70.
- Race: No data
- Demographic information: No data - Clinical history:
- No information provided.
- Controls:
- No information provided.
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: patch test (epicutaneous test)
ADMINISTRATION
- Type of application: occluded and uoccluded
- Description of patch:
- Group A: occluded patch with the edges sealed using Blenderm; it was found the Blenderm induced reactions at the edges of the patches; the same group of subjects was treated again with both occluded and unoccluded samples. The occluded application in this case was made by saturation of the gauze pad of a Band-Aid Plastic Strip (Johnson & Johnson) which was applied tightly to the skin but not sealed.
- Group B: occluded patches using Band-Aid Plastic Strips as above
- Vehicle / solvent: isopropanol
- Concentrations: 6%
Results and discussion
- Results of examinations:
- MGK Repellent 874 was not a skin irritant or a skin sensitiser in humans at a concentration of 6%.
Applicant's summary and conclusion
- Conclusions:
- MGK Repellent 874 was not a skin irritant or a skin sensitiser in humans at a concentration of 6%.
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