Registration Dossier
Registration Dossier
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EC number: 239-784-6 | CAS number: 15687-27-1
Sediment toxicity
Administrative data
- Endpoint:
- sediment toxicity: short-term
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- concentrations not specified with regard to dry or wet weight
Data source
Reference
- Reference Type:
- publication
- Title:
- Suitability of Standardized Acute Toxicity Tests for Marine Sediment Assessment: Pharmaceutical Contamination
- Author:
- Maranho LA, Garrido-Pérez MC, DelValls TA, Martín-Díaz ML
- Year:
- 2 015
- Bibliographic source:
- Water Air Soil Pollut 226: 65
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- bioluminescence inhibition of the bacteria Vibrio fischeri (Microtox® Solid Phase Test (SPT))
- GLP compliance:
- no
Test material
Constituent 1
- Specific details on test material used for the study:
- Purity: >= 98%
Source: Sigma-Aldrich (Madrid, Spain)
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- The highest concentrations of the six selected pharmaceuticals were measured in the spiked sediments (Jelic et al. 2009). Detailed methodology is described in Maranho et al. (2014).
Test substrate
- Vehicle:
- yes
- Details on sediment and application:
- PREPARATION OF SPIKED SEDIMENT
- Pooling or mixing of different substrates: no
- Method of mixing: rotation mixer
- Details of spiking: spiked sediment of highest concentration diluted with reference sediment for further test concentrations
- Equilibration time: 7 d
- Equilibration conditions: 4 °C, dark
- Controls: reference sediment and reference sediment spiked with vehicle
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): DMSO
- Concentration of vehicle in test medium (stock solution and final test solution): 0.001% v/v
- Evaporation of vehicle before use: no data
Test organisms
- Test organisms (species):
- other: Vibrio fisheri (Microtox Solid Phase Test, SPT)
Test conditions
- Nominal and measured concentrations:
- nominal: 500 ng/g
measured: 405±50 ng/g
Results and discussion
Effect concentrations
- Duration:
- 30 min
- Dose descriptor:
- EC50
- Effect conc.:
- 100.6 other: µg/kg
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- other: inhibition of bioluminescence
- Remarks on result:
- other: not specified if test result is based on dry or wet weight
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
