Registration Dossier
Registration Dossier
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EC number: 239-784-6 | CAS number: 15687-27-1
Toxicity to aquatic plants other than algae
Administrative data
- Endpoint:
- toxicity to aquatic plants other than algae
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions; (e.g. no details on test substance documented).
Data source
Reference
- Reference Type:
- publication
- Title:
- Aquatic ecotoxicity of pharmaceuticals including the assessment of combination effects
- Author:
- Cleuvers M
- Year:
- 2 003
- Bibliographic source:
- Toxicol Letters 142: 185-194
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: ISO/WD 20079; (ISO 2001)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium 2-(4-isobutylphenyl)propionate
- EC Number:
- 250-477-6
- EC Name:
- Sodium 2-(4-isobutylphenyl)propionate
- Details on test material:
- - Name of test material (as cited in study report): Ibuprofen sodium
- Purity: analytical grade
- Supplier: Sigma Aldrich Chemie GmbH, Taufkirchen, Germany
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- Lemna minor
- Details on test organisms:
- TEST ORGANISM
- Common name: Duckweed
ACCLIMATION
- Culturing media and conditions (same as test or not): yes
Study design
- Test type:
- not specified
- Water media type:
- saltwater
- Limit test:
- no
- Total exposure duration:
- 7 d
Test conditions
- Test temperature:
- 25 ±2°C
- Nominal and measured concentrations:
- nominal test concentrations: 0 (control), 1, 3.2, 10, 32 and 100 mg/L
Results and discussion
Effect concentrations
- Duration:
- 7 d
- Dose descriptor:
- EC50
- Effect conc.:
- 22 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
