Registration Dossier
Registration Dossier
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EC number: 213-313-4 | CAS number: 936-49-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Title:
- No information
- Author:
- Anonymous
- Year:
- 2 007
- Bibliographic source:
- IUCLID4 data set, 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Hazelton protocol No. P 2/152, 1st revision
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-phenyl-2-imidazoline
- EC Number:
- 213-313-4
- EC Name:
- 2-phenyl-2-imidazoline
- Cas Number:
- 936-49-2
- Molecular formula:
- C9H10N2
- IUPAC Name:
- 2-phenyl-4,5-dihydro-1H-imidazole
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- male
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: animals were their own control
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 24h exposure
- Observation period:
- 72h
- Number of animals:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24h
- Score:
- 3
- Max. score:
- 8
- Remarks on result:
- other: abraded
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 72h
- Score:
- 4
- Max. score:
- 8
- Remarks on result:
- other: abraded
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24h
- Score:
- 3
- Max. score:
- 8
- Remarks on result:
- other: abraded
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 72h
- Score:
- 2.33
- Max. score:
- 8
- Remarks on result:
- other: abraded
- Irritant / corrosive response data:
- AVERAGE SCORE
- Erythema:
24 h mean 3.0 (abraded), 3.17 (unabraded
72 h mean 4.0 (abraded), 4.0 (unabraded)
- Edema:
24 h mean 3.0 (abraded), 2.83 (unabraded)
72 h mean 2.33 (abraded), 2.17 (unabraded)
REVERSIBILITY: no data
OTHER EFFECTS: greenish colouration of treated skin
Any other information on results incl. tables
See also attached IUCLID4 dossier.
Conclusion: substance is irritating to skin: classification according to DSD Xi;R38; according to CLP as skin irritant catgeory 2 with H315 (causes skin irritation)
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Xi;R38 Criteria used for interpretation of results: EU
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