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EC number: 272-902-4 | CAS number: 68919-76-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012-10-05 to 2012-11-29
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was performed according to OECD 423 and EU method B.1 tris in a GLP-certified testing facility
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Test material form:
- other: liquid
- Details on test material:
- Sponsor's identification: 400112
Date received: 24 September 2012
Container: brown glass flask (n= I)
Quantity: 93.15 g (container + contents)
Batch No: 0001273679
Colour: yellow-brown
Production date: May 2011
Expiry date: May 2013
Storage: room temperature
Purity: 100% (not purified but used as synthesized)
Composition: UVCB substance
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- effective dose: 2000 mg/kg bw
corresponding to a volume of 2.05 mL/kg bw
using a suitable syringe graduated fitted with an oesophageal metal canula - No. of animals per sex per dose:
- 6
- Control animals:
- yes
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- one female was found dead on day 1 after application; the animal showed decrease in spontaneous activity and in muscle tone, diarrhoea and piloerection.
- Clinical signs:
- other: decrease in spontaneous activity (5/5), muscle tone (5/5), righting reflex (2/5), myosis (3/5), salivation (1/5), lacrymation (1/5), piloerection (5/5) and diarrhoea (2/5). Behaviour was normal from day 4.
- Gross pathology:
- Macroscopic examination of the dead animal revealed a thinning of the forestomach and red spots on the forestomach. Lysis of the intestinal tract incl. duodenum, jejunum, ileon, caecum, and colon was noted in the dead animal. No other effects were observed.
Macroscopic examination of the surviving animals (5/6) at the end of the study did not reveal treatment-related changes.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified according to EU regulation
- Conclusions:
- The LD50 of the test item 400112 was higher than 2000 mg/kg body weight by oral route in the rat.
- Executive summary:
The test item 400112 was administered to a group of 6 female Sprague Dawley rats at a single dose of 2000 mg/kg body weight. The experimental protocol was established according to OECD guideline No. 423 and the test method B.1 tris of the Council regulation No. 440/2008.
One rat treated at 2000 mg/kg b.w. died at 25 h and 50 min post-dose during the first step of the study. The mortality was preceded by decrease in spontaneous activity and in muscle tone, diarrhoea and piloerection.
In conclusion, the LD50 of the test item 400112 is higher than 2000 mg/kg body weight by oral route in the rat.
In accordance with Regulation EC No. 1272/2008 the test item does not have to be classified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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