Registration Dossier
Registration Dossier
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EC number: 700-325-4 | CAS number: 1149346-12-2
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02 July - 21 July, 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study has been performed according to OECD and/or EC guidelines, and according to GLP principles.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- Pow
- Partition coefficient:
- > 3 200 000
- Temp.:
- 25 °C
- pH:
- ca. 7
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 6.5
- Temp.:
- 25 °C
- pH:
- ca. 7
- Details on results:
- The components of the test substance eluted with retention times of > 2 minutes. The retention time of 2,4-DDT was 2.01 minutes. Hence, it was concluded that the log Pow of the components of the test substance was > 6.5 (Pow > 3.2E 6).
Using 75/25 (v/v) methanol/water as the mobile phase and when injecting the HXL-8366 solution in methanol it was confirmed that none of the HXL-8366 peaks elute before 2,4-DDT. - Conclusions:
- Using the HPLC method, the Pow and log Pow values of HXL-8366 are > 3.2E6 and > 6.5, respectively.
Reference
Description of key information
The Pow and log Pow values of HXL-8366 are > 3.2E6 and > 6.5, respectively.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 6.5
- at the temperature of:
- 20 °C
Additional information
Using the HPLC method, the Pow and log Pow values of HXL-8366 are > 3.2E6 and > 6.5, respectively.
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