1,4-bis(p-tolylamino)anthraquinone

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics, other

Remarks:

Toxicokinetics assumption

Type of information:

other: Toxicokinetics assumption

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Toxicokinetik assumption

Data source

Reference

Reference Type:

other company data

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Objective of study:

toxicokinetics

Principles of method if other than guideline:

Toxicokinetics assumption.

GLP compliance:

no

Test animals

Species:

other: Toxicokinetics assumption

Strain:

other: Toxicokineticsassumption

Details on test animals or test system and environmental conditions:

Toxicokinetics assumption.

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on absorption:

ABSORPTION:
The most imported physicochemical data (molecular weight, water solubility and logPow) determining the toxicokinetik behaviour (ADME) of the 6 members of the proposed anthraquinone category are all in the same range. The molecular weight of the six category members is between 418.487 and 534.644 g/mol. The water solubility is in general very low, and is in all category members < 0.02 mg/liter. The log Pow of all category members is >8 (range 8.2 and 10.7, experimental).

Each of the considered parameter alone indicates a low bioavailability. Taken all parameters together a toxicological relevant absorption is not assumed.

Details on distribution in tissues:

DISTRIBUTION:
In general, the smaller the molecule, the wider the distribution. Based on the molecular weights of the group members, the distribution of the group members is limited. This assumption is supported by the very low water solubility and high log Pow which are not favourable for active transport or passive diffusion through body membranes

Details on excretion:

Excretion:
Metabolism is considered as not relevant, because no absorption is predicted. In case of a negligible absorption, due to the higher water solubility of the metabolites compared with their parent substances a rapid excretion is predicted. Therefore, bioaccumulation is not expected.

Metabolite characterisation studies

Metabolites identified:

no

Details on metabolites:

METABOLISM:
Metabolism is considered as not relevant, because no absorption is predicted. In case of a negligible absorption, no hydrolysis products are expected in toxicologically significant doses. There are no chemical structures or moieties which could be transformed by hydrolytical attack. It can be concluded that cleavage neither of the antraquinone group nor of the amino group will occur.

There are no experimental data available. In a QSAR evaluation (OECD Toolbox V 4.1) the predicted main phase I metabolic pathways are the oxidation of the alkyl side-chains and/or oxidation of the aromatic ring systems including an diimine formation. A reduction of the benzoquinone to the hydroxybenzoquinone is also possible (see Appendix 2; Reinblau RLW, CAS no. 41611-76-1 as example for the anthraquinone category).

All available mutagenicity assays are negative (in vitro tests with and without metabolic activation). This indicates that no genotoxic degradation products are produced.