Registration Dossier
Registration Dossier
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EC number: 219-094-1 | CAS number: 2356-53-8
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From March 2018 to May 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- July 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- May 2008
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- flask method
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: D653 22_02_2018
- Expiration date of the lot/batch: Feburary 2023
- Purity test date: 2018/02/27 - Key result
- Water solubility:
- 0.124 g/L
- Temp.:
- 20 °C
- pH:
- 7.5
- Details on results:
- No pH adjustement was performed in the main test.
- Conclusions:
- The test item water solubility at 20°C and pH 7.5 is 0.124 g/L.The test item is considered slightly soluble in water
- Executive summary:
The test item water solubility was determined with the flask method according to recognised guidelines. No deviation from the guidelines was observed during the study.
A preliminary test was performed in order to estimate the water solubility of the test item.
In the main test, the test iem water solubility is 0.124 g/l at 20°C and pH 7.5. The test item is considered slightly soluble in water
- Endpoint:
- water solubility
- Type of information:
- not specified
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- No details on method are given, however the data source is considered reliable.
- Principles of method if other than guideline:
- no data
- GLP compliance:
- no
- Type of method:
- other: no data
- Remarks on result:
- other: Partly soluble
- Conclusions:
- Partly soluble
- Executive summary:
1,2-dichloro-1,1,2-trifluoro-2-(trifluoromethoxy)ethane is reported to be partly soluble in water.
Referenceopen allclose all
In the preliminary test results,the test item was still not completely dissolved in 100 ml of water
In the main test, the concentrations measured in the two last vessels do not differ by more than 15% therefore, the test was considered as valid.
| Sample (stirring time) | Solubility (g/L) | Average Solubility per sample (g/L) | pH |
| One Day | 0.111 0.110 0.110 |
0.110 | 7.5 |
| Two days | 0.134 0.134 0.134 |
0.134 | 7.5 |
Three days |
0.129 0.128 0.128 |
0.128 | 7.5 |
Description of key information
The test item water solubility was experimentally determined in a key study performed under GLP according to OECD guideline No. 105.
The results obtained in the key study were confirmed by a supporting study.
Key value for chemical safety assessment
- Water solubility:
- 124 mg/L
- at the temperature of:
- 20 °C
Additional information
Based on its water solubility value, the test item is considered partly soluble in water.
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