Registration Dossier
Registration Dossier
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EC number: 219-094-1 | CAS number: 2356-53-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 20 July 1987 to 13 August 1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,2-dichloro-1,1,2-trifluoro-2-(trifluoromethoxy)ethane
- EC Number:
- 219-094-1
- EC Name:
- 1,2-dichloro-1,1,2-trifluoro-2-(trifluoromethoxy)ethane
- Cas Number:
- 2356-53-8
- Molecular formula:
- C3Cl2F6O
- IUPAC Name:
- 1,2-dichloro-1,1,2-trifluoro-2-(trifluoromethoxy)ethane
- Reference substance name:
- Methylic Adduct
- IUPAC Name:
- Methylic Adduct
- Details on test material:
- - Name of test material (as cited in study report): Ethane,1,2-dichloro-1,1,2-trifluoro-2-trifluoromethoxy
- Substance type: pure substance
- Physical state: liquid
- Analytical purity: not reported
- Impurities (identity and concentrations): not reported
- Composition of test material, percentage of components: not reported
- Isomers composition: not reported
- Purity test date: not reported
- Lot/batch No.: F104206
- Expiration date of the lot/batch: not reported
- Stability under test conditions: not reported
- Storage condition of test material: in the dark under ambient conditions.
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 3 (2 males + 1 female)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Remarks:
- (including at 1h time point)
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Remarks:
- (including at 1h time point)
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Remarks:
- (including at 1h time point)
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Remarks:
- (including at 1h time point)
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Remarks:
- (including at 1h time point)
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Remarks:
- (including at 1h time point)
Any other information on results incl. tables
In all animals, at all time points, no dermal irritation was noted.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- CLP-Regulation (EC) No 1272/2008
- Conclusions:
- No dermal irritation was noted.
It was concluded that 1,2-dichloro-1,1,2-trifluoro-2-(trifluoromethoxy)ethane is not irritant to rabbit skin. - Executive summary:
The IRI project No.238237, includes an acute oral toxicity test, an eye irritation test and a dermal irritation test.
In the dermal irritation test, three rabbits were treated with 0.5 ml of 1,2-dichloro-1,1,2-trifluoro-2-(trifluoromethoxy)ethane in a
4 -hour semi-occluded exposure. No irritation was noted following the exposure.
It is concluded that 1,2-dichloro-1,1,2-trifluoro-2-(trifluoromethoxy)ethane is not irritant to rabbit skin.
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