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EC number: 201-321-0 | CAS number: 81-07-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Summary of Acutic tox results:
Short term toxicity to fish:
No. of studies reviewed for Short-term toxicity to fish from reliable sources having Klimisch rating 2.
The summary of the results are presented below:
Sr.No |
Endpoint |
Effect values |
Basis for effects |
Duration |
Species |
CAS No. |
Sources |
1 |
LC50 |
18300 mg/L |
Mortality |
96 hrs. |
Pimephales promelas |
81-07-2 |
Experimental data |
2 |
NOEC |
2500 mg/L |
Behaviour |
24 - 26 hours post fertilization |
Danio rerio |
81-07-2 |
Experimental data from publication |
3 |
LC50 |
7272.4 mg/L |
Development |
24 to 72 hour(s) |
Danio rerio |
81-07-2 |
Experimental data from publication |
4 |
LC50 |
293.411 mg/L |
Mortality |
96 hrs. |
Leuciscus idus |
81-07-2 |
Predicted data from QSAR |
5 |
LC50 |
5585.3 mg/L |
Development |
144 hrs.(6 days) |
Danio rerio |
81-07-2 |
Experimental data from publication |
6 |
EC50 |
4755.5mg/L |
Development |
144 hrs.(6 days) |
Danio rerio |
81-07-2 |
Experimental data from publication |
7 |
LC50 |
>100 mg/L |
Mortality |
24-96 hrs. |
Poecilia reticulata |
Read across 128-44-9 |
Experimental data |
By applying weight of evidence approach to the target substance 1,2-benzisothiazol-3(2H)-one 1,1-dioxide and the read across substance 1,2-benzisothiazol-3(2H)-one 1,1-dioxide, sodium salt (which have more than 87.8% structural similarity),the endpoint value was found to vary between LC50 = >100 mg/L to 18300 mg/L in a 24 hrs.study to 96 hrs.study on the basis of mortality effect,EC50=4755.5mg/L basis of Development effect and NOEC for24 - 26 hours post fertilization period was reported as 2500 mg/L
Thus considering the CLP Criteria for aquatic classification of the substance, it is concluded that the test substance 1,2-benzisothiazol-3(2H)-one 1,1-dioxide does not exhibits short term toxicity to fish (Leuciscus idus, Danio rerio ,Pimephales promelas and Poecilia reticulata).
Long term toxicity to fish:
In a long term toxicity study, 451 Danio sp. (Danio) Zebrafish embryo(s) were treated with Saccharin.
Embryo(s) and larva were observed for highest non-teratogenic concentration (HNTC), spontaneous tail coilings in zebra fish embryos and eleutheroembryonic and larval locomotor activity for 144 hours post fertilization.
No effect were observed on highest non-teratogenic concentration (HNTC), spontaneous tail coilings in zebra fish embryos and eleutheroembryonic and larval locomotor activityfor 144 hours post fertilizationofEmbryo(s) and larva of treated fish as compared to control.
Therefore, NOEC was considered to be 2500 mg/l when 451 Danio sp. (Danio) Zebrafish embryo(s) treated with Saccharin for 144 hours post fertilization.
Short term toxicity to aquatic invertebrates
The effective concentration (EC50) value of 1,2-benzisothiazol-3(2H)-one 1,1-dioxide in aquatic invertebrate (Daphnia pulex) in a 48 hr study on the basis of intoxication effect was estimated to be 104.403 mg/L.Thus,considering the CLP Criteria for aquatic classification of the substance , it is concluded that 1,2-benzisothiazol-3(2H)-one 1,1-dioxide does not exhibit short term toxicity to aquatic invertebrate (Daphnia pulex).
Long-term toxicity to aquatic invertebrates
According to annex IX of column I ; Long-term toxicity testing on invertebrate (species : Daphnia magna) need not to be conducted as it is already provided as a part of Annex VII requirements.Therefore this end point was considered for waiver.
Toxicity to aquatic algae and cyanobacteria
After 72 hours of exposure to 1,2-benzisothiazol-3(2H)-one 1,1-dioxide (CAS No. 81-07-2) to various nominal test concentration, EC50 was found to be 541170mg/L (>200mg/l with an R square of 0.961) and EC25 was found to be 569.581 mg/L (with an R square of 0.961).
Toxicity to microorganisms
The effective concentration (EC50) value of 1,2-benzisothiazol-3(2H)-one 1,1-dioxide in microorganism (Tetrahymena thermophila) in a 48 hr study on the basis of population effect was estimated to be 123.04 mg/L.
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