Registration Dossier
Registration Dossier
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EC number: 201-321-0 | CAS number: 81-07-2
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
From the information on absorption, distribution, metabolism and excretion of saccharin to six adult female subjects who used saccharin-containing products in their diet; the bio-accumulation potential of saccaring within the human body appears to be low. The kinetic parameters indicate that saccharin is distributed as a function of lean rather than total body mass. This observation suggests that there may be one or more high retention compartments for saccharin.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
From the studies conducted in humans as well as rats that were administered saccarin as part of their diet, majority of the administered saccharin was excreted out of the living system unmetabolized via the urine and some through feaces. Majority of the toxico-kinetic studies report no metabolites.Thus, saccharin is expected to have low bio-accumulation potential under normal concentrations of intake bby humans and animals.
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