Registration Dossier
Registration Dossier
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EC number: 225-063-3 | CAS number: 4637-24-5
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: OECD guideline study, no GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- no
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- 1,1-dimethoxytrimethylamine
- EC Number:
- 225-063-3
- EC Name:
- 1,1-dimethoxytrimethylamine
- Cas Number:
- 4637-24-5
- Molecular formula:
- C5H13NO2
- IUPAC Name:
- 1,1-dimethoxy-N,N-dimethylmethanamine
- Details on test material:
- IUCLID4 Test substance: other TS
TS-Freetext:
Dimethylformamid-dimethylacetal, no further data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- For the quantitative determination of the vapor concentration, a gas chromatographical method was used.
- Duration of exposure:
- 4 h
- Concentrations:
- 0.89, 4.2, 11.0, 16.0, and 19.9 mg/l
- No. of animals per sex per dose:
- 10
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 12.16 mg/L air
- Exp. duration:
- 4 h
- Clinical signs:
- other: During exposure: Some animais wiping their snouts, some shaking their heads, lid closure, slight to pronounced, spasmodic respiration, lacrimation, salivation, piloerection, apathy. After exposure: Agony and lateral position (1 animal of test group 1); t
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- The LC50 after inhalation of the test item was calculated to be 12.16 mg/L.
- Executive summary:
After a 4-hour inhalation of the vapor of the test substance, the LC50 was calculated to be 12.16 mg/L.
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