Registration Dossier
Registration Dossier
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EC number: 225-063-3 | CAS number: 4637-24-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well documented guideline study with deviations, no GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Principles of method if other than guideline:
- Method: other: BASF-test
- GLP compliance:
- no
- Test type:
- other: BASF-test
- Limit test:
- yes
Test material
- Reference substance name:
- 1,1-dimethoxytrimethylamine
- EC Number:
- 225-063-3
- EC Name:
- 1,1-dimethoxytrimethylamine
- Cas Number:
- 4637-24-5
- Molecular formula:
- C5H13NO2
- IUPAC Name:
- 1,1-dimethoxy-N,N-dimethylmethanamine
- Details on test material:
- IUCLID4 Test substance: other TS
TS-Freetext:
Dimethylformamid-dimethylacetal, no further data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Doses:
- 2150 and 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- in both treatment groups
2150 mg/kg bw: 1 male rat
5000 mg/kg bw: 2 female rats - Gross pathology:
- One female animal:
Stomach: atonic.
One female animal:
Organs: na abnormalities detected.
One male animal:
cadaverous, diagnosis not possible.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- The oral LD50 of the test item was found to be greater than 5000 mg/kg bw.
- Executive summary:
After oral application of the test substance to 5 male and 5 female Wistar rats per dosage group via gavage, the oral LD50 was found to be greater than 5000mg/kg bw.
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