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Environmental fate & pathways

Hydrolysis

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Administrative data

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Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
21-11-2012 - 31-05-2013
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
GLP compliance:
yes (incl. QA statement)
Specific details on test material used for the study:
Details on properties of test surrogate or analogue material:
PHYSICO-CHEMICAL PROPERTIES
- Boiling point: 107 °C
- Water solubility (under test conditions): > 1000 g/L
- pH 12-14
The production method yields the substance in an approximately 50% aqueous solution with a content of sodium hydroxide.
Analytical monitoring:
yes
Buffers:
- pH: 4, 7, 9
- Composition of buffer: (Concentration in mmol dm-3)
4: Citric acid 0.6; Sodium chloride 0.4; Sodium hydroxide 0.7
7: Disodium hydrogen orthophosphate (anhydrous) 0.3; Potassium dihydrogen orthophosphate 0.2; Sodium chloride 0.2
9: Disodium tetraborate 0.1; sodium chloride 0.2
Duration:
120 h
pH:
4
Initial conc. measured:
> 0.001 - < 0.001 g/L
Duration:
120 h
pH:
7
Initial conc. measured:
> 0.001 - < 0.001 g/L
Duration:
120 h
pH:
9
Initial conc. measured:
> 0.001 - < 0.001 g/L
Number of replicates:
2 replicates pr pH value
Positive controls:
not specified
Negative controls:
not specified
Transformation products:
not specified
% Recovery:
>= 96.4 - < 100
pH:
4
Temp.:
50 °C
Duration:
120 h
Remarks on result:
other: 101%
% Recovery:
> 94 - < 98.6
pH:
7
Temp.:
50 °C
Duration:
120 h
% Recovery:
ca. 100
pH:
9
Temp.:
50 °C
Duration:
120 h
Remarks on result:
other: >103 - < 104%
Key result
pH:
4
Temp.:
25 °C
DT50:
> 1 yr
Type:
not specified
Remarks on result:
other: Estimated from results at 50°C
Key result
pH:
7
Temp.:
25 °C
DT50:
> 1 yr
Type:
not specified
Remarks on result:
other: Estimated from results at 50°C
Key result
pH:
9
Temp.:
25 °C
DT50:
> 1 yr
Type:
not specified
Remarks on result:
other: Estimated from results at 50°C
Validity criteria fulfilled:
yes
Remarks:
For all: Linearity of detector response/concentration in the range of 0.10-1.0 mg/L. For pH: second-order behavier. At pH 7 & 9: First-order behavior with correlation coefficents (r2) ≥ 0.998
Conclusions:
The test item was found not to hydrolyse neither at pH 4; 7 nor 9. The half-life is expected to be greater than 1 year at 25 ºC.
Remark: the test solution contains NaOH due to the production method.
Executive summary:

This test was performed according to the OECD Guideline 111 under GLP compliance. The test item was found not to hydrolyse neither at pH 4; 7 nor 9. The half-life is expected to be greater than 1 year at 25  ºC.

Description of key information

This test was performed according to the OECD Guideline 111 under GLP compliance. The test item was found not to hydrolyse neither at pH 4; 7 nor 9. The half-life is expected to be greater than 1 year at 25  ºC.

Key value for chemical safety assessment

Half-life for hydrolysis:
1 yr
at the temperature of:
25 °C

Additional information