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EC number: 257-077-0 | CAS number: 51240-95-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02 June 1986 - 05 June 1986
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,1,3,3-tetramethylbutyl peroxyneodecanoate
- EC Number:
- 257-077-0
- EC Name:
- 1,1,3,3-tetramethylbutyl peroxyneodecanoate
- Cas Number:
- 51240-95-0
- Molecular formula:
- C18H36O3
- IUPAC Name:
- 2,4,4-trimethylpentan-2-yl 2,2,3,5-tetramethylhexaneperoxoate; 2,4,4-trimethylpentan-2-yl 2,2-diethylhexaneperoxoate; 2,4,4-trimethylpentan-2-yl 2,2-dimethyloctaneperoxoate; 2,4,4-trimethylpentan-2-yl 2,4-dimethyl-2-(propan-2-yl)pentaneperoxoate; 2,4,4-trimethylpentan-2-yl 2-ethyl-2,5-dimethylhexaneperoxoate
- Details on test material:
- - Chemical name: Neodecane peroxoic acid 1,1,3,3-tetramethyl butyl ester
- Appearance: Colouless clear liquid
- CAS-reg. no.: 51240-95-0
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: The Broekman Institute, Someren, The Netherlands
- Age at study initiation: approximately 10 weeks old
- Weight at study initiation: 2111, 2003 and 2407 grams
- Housing: indiVidually housed in metal cages with perforated floors
- Diet (e.g. ad libitum): ad libitum, standard laboratory animal diet (100 g per day), obtained from Hope Farms, Woerden (LK-01, pellet diameter 4 mm).
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19.5-21.5
- Humidity (%): 55-75
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: 02 June 1986 - 05 June 1986
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml
- Concentration (if solution): as such - Duration of treatment / exposure:
- 72 hours
- Observation period (in vivo):
- The eyes are examined 1, 24, 48, and 72 hours after instillation of the test substance. After recording the observations at 24 hours, the eyes of the rabbits may be further examined with the aid of fluorescein stain. The untreated eye is used as reference. Other observations, generally performed on day 7, 14 and/or 21, may be needed in order to sufficiently evaluate reversibility or irreversibility.
- Number of animals or in vitro replicates:
- 3 females
- Details on study design:
- SCORING SYSTEM:
Scoring system eye irritation
Cornea: degree of density (area most dense taken for reading)
0 No ulceration or opacity
1 Scattered or diffuse areas of opacity (other than slight dulling of normal lustre), details of iris clearly visible
2 Easily discernible translucent areas, details of iris slightly obscured
3 Nacrous areas, no details of iris visible, size of pupil barely discernible
4 Opaque cornea, iris not discernible through the opacity
Iris
0 Normal
1 Markedly deepened rugae, congestion, swelling, moderate circumcorneal hyperaemia or injection, any of these or combination of any thereof, iris still reacting to light (sluggish reaction is positive)
2 No reaction to light, haemorrhage, gross destruction (any or all of these)
Conjunctivae
Redness (refers to palpebral and bulbar conjunctivae cornea and iris)
0 Blood vessels normal
1 Some blood vessels definitely hyperaemic
(injected)
2 Diffuse, crimson colour, individual vessels not easily discernible
3 Diffuse, beefy red
Chemosis (lids and/or nictitating membranes)
0 No swelling 0
1 Any swelling above normal (includes nictitating membranes)
2 Obvious swelling with partial eversion of lids
3 Swelling with lids about half-closed
4 Swelling with lids more than half-closed
TOOL USED TO ASSESS SCORE: fluorescein
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- 1 animal
- Time point:
- 24/48/72 h
- Score:
- 0.67
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: all other scores were 0 for 24-48-72 hours, see table below.
- Irritant / corrosive response data:
- One hour after dosing slight conjunctival redness and chemosis were observed in all animals; in two of them these findings disappeared within the next twenty-four hours In the third animal slight conjunctival hyperaemia was observed for forty-eight hours. Adverse findings on the cornea and the iris were not observed in any of the rabbits during the entire observation period. Treatment of the eyes with fluorescein 24 hours after instillation of the test substance did not reveal any epithelial damage. Signs of systemic intoxication were not observed.
Any other information on results incl. tables
Rabbit No and sex |
Region of the eye |
Hours after instillation |
Average 24-48-72 hours |
|||||
1 |
24 |
48 |
72 |
4-7-14(days) |
|
|||
1-f |
Cornea |
Degree of opacity |
0 |
0 |
0 |
0 |
0 |
0 |
|
Iris |
0 |
0 |
0 |
0 |
0 |
0 |
|
|
Conjunctivae |
Redness |
1 |
0 |
0 |
0 |
0 |
0 |
|
|
Chemosis |
1 |
0 |
0 |
0 |
0 |
0 |
2-f |
Cornea |
Degree of opacity |
0 |
0 |
0 |
0 |
0 |
0 |
|
Iris |
|
0 |
0 |
0 |
0 |
0 |
0 |
|
Conjunctivae |
Redness |
1 |
0 |
0 |
0 |
0 |
0 |
|
|
Chemosis |
1 |
0 |
0 |
0 |
0 |
0 |
3-f |
Cornea |
Degree of opacity |
0 |
0 |
0 |
0 |
0 |
0 |
|
Iris |
|
0 |
0 |
0 |
0 |
0 |
0 |
|
Conjunctivae |
Redness |
1 |
1 |
1 |
0 |
0 |
0.67 |
|
|
Chemosis |
1 |
0 |
0 |
0 |
0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- One hour after dosing slight conjunctival redness and chemosis were observed in all animals; in two of them these effects disappeared within the next twenty-four hours whereas in the third animal slight conjunctival hyperaemia was observed for forty-eight hours (mean score 24-48-72 hours is 0.67). Therefore the substance does not need to be classified as eye irritant.
- Executive summary:
The substance was tested in the rabbit acute eye irritation/corrosion test to determine its possible irritating or corrosive effects. Instillation of 0.1 ml of the test substance in one of the eyes of three female rabbits resulted in slight redness and swelling of the conjunctivae. In two of the animals the conjunctival effects disappeared within twenty-four hours, whereas in one animal slight redness persisted for forty-eight hours. No adverse effects on the cornea and the iris were observed in any of the rabbits during the entire observation period.
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