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Diss Factsheets
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EC number: 203-527-6 | CAS number: 107-86-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
Repeated oral toxicity:
An OECD guideline study (No. 415) was reported from BASF (2002). Male and female rats were given concentrations of 50, 200 and 800 ppm (= about 6, 21 and 77 mg/kg) over a study period of 18 weeks over the drinking water. No substance-related signs or any disturbance of behaviour was noted in all parental animals during the entire administration period. One high dose female was found dead during premating week 10. Erosions/ulcerations of glandular stomach mucosa was found at necropsy, but this was assessed as being not causative for death. No other mortalities occurred. The NOAEL was found to be 77 mg/kg/d for systemic toxicity for male and female parental animals. The NOEL was 21 mg/kg in this study, based on the reduced water and food consumption at the top dose level.
Classification according to Directive 67/548/EEC for repeated acute oral toxicity is not warranted.
Repeated inhalation toxicity:
BASF (1994) reported an OECD guideline 412 study. In this study, male and female rats were given vapour concentrations of 30, 100 and 300 ppm (= 0.10, 0.34 and 1.02 mg/l) over a study period of 28 days. The test substance was given for 6 hours each working day. Concentrations at or above 100 ppm (= 0.34 mg/l) caused irritation of the upper respiratory tract as demonstrated mainly by the concentration-dependent focal metaplasia of respiratory epithelium into squamous epithelium. No systemic toxic effects occurred up to the high concentration of 300 ppm. The NOAEC for systemic toxicity was 300 pm for both genders, the NOEC was 30 ppm (both sexes). The LOAEC for local irritation of the upper respiratory tract was found to be 100 ppm for male and female rats.
According to the effects found in this study, classification proposal according to Directive 67/548/EEC concerning repeated inhalation toxicity can be made with R 48.
No data ara available for repeated dermal toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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