Registration Dossier
Registration Dossier
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EC number: 223-786-9 | CAS number: 4073-98-7
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable well documented report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 961
- Report date:
- 1961
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- BASF-Test:
Standardised study to determine the acute toxicity of the test item in male and female mice after single i.p. application (observation period: 14 days). - GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- p-Xylidinbase
- IUPAC Name:
- p-Xylidinbase
- Details on test material:
- - Name of test material (as cited in study report): p-Xylidinbase; 4,4'-Diamino-2,2',5,5'-tetramethyldiphenylmethan
no further data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: aequeous solution with traganth
- Doses:
- 100, 200, 400, 800 mg/kg bw
- No. of animals per sex per dose:
- - 100 mg/kg bw: 10
- 200 mg/kg bw: 10
- 400 mg/kg bw: 10
- 800 mg/kg bw: 10 - Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 800 mg/kg bw
- Based on:
- test mat.
- Mortality:
- - 800 mg/kg bw: 2/10,
- Clinical signs:
- - 400 and 800 mg/kg bw: slight stagger; apathy, adbominal position
- Body weight:
- no data
- Gross pathology:
- no data
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
