Registration Dossier
Registration Dossier
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EC number: 414-420-0 | CAS number: - SPE 93279
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Remarks:
- Follows standard guidelines, under GLP
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- A mixture of: 2-ethylhexyl mono-D-glucopyranoside; 2-ethylhexyl di-D-glucopyranoside
- EC Number:
- 414-420-0
- EC Name:
- A mixture of: 2-ethylhexyl mono-D-glucopyranoside; 2-ethylhexyl di-D-glucopyranoside
- Cas Number:
- 125590-73-0
- Molecular formula:
- (C6H10O5)n, C8H18O n = 1,2
- IUPAC Name:
- Reaction mass of 2-ethylhexyl mono-D-glucopyranoside and 2-ethylhexyl di-D-glucopyranoside
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Vehicle:
- water
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male 2000 mg/kg bw, number of animals: 5, number of death: 0
Male 5000 mg/kg bw, number of animals: 5, number of death: 2
Female 2000 mg/kg bw, number of animals: 5, number of death: 0
Female 5000 mg/kg bw, number of animals: 5, number of death: 2 - Clinical signs:
- other: Signs of toxicity related to dose levels: Death were observed between 5 hours and 2 days after dosing. Pilo-erection, hunched posture, abnormal gait, lethargy, decreased respiratory rate and pallor of the extremities were observed in both sexes at both d
- Gross pathology:
- Effects on organs: no macroscopic findings were observed in any animals surviving treatment. Congestion of blood vessels of the small and large intestines was observed in one female which died following 5000 mg/kg.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
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