Registration Dossier
Registration Dossier
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EC number: 239-743-2 | CAS number: 15667-63-7
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Type:
- log Pow
- Partition coefficient:
- 0.12
- Temp.:
- 20 °C
- pH:
- ca. 3.5 - ca. 6
- Conclusions:
- The partition cefficient n-octanol/water of the test item was determined according to OECD117 to be 0.12 (logPow).
Reference
The pH value of an aqeous solution is in the weak acid range, depending on concentration and the (limited) extent of hydrolysis. Because the substance has no ionizable functional groups, the partition coefficient is not dependent on the exact pH value.
The shake-flask method was not applicated, because the hazardous properties of the substance demand short handlig times.
The experimental result matches well with the results of a calculation done with the EPISUITE program (Log Pow (calc) = 1.67), which is also part of the study report.
Description of key information
The partition cefficient n-octanol/water of Acrolein cyanhydrin acetate (ACA) was experimentally determined in an OECD guidline study according to OECD117 under GLP conditions.
The logPow was esteblished to be 0.12 (logPow). The low logPow was further supported by a calculation method.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 0.12
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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