Registration Dossier
Registration Dossier
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EC number: 200-076-7 | CAS number: 51-03-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-(2-butoxyethoxy)ethyl 6-propylpiperonyl ether
- EC Number:
- 200-076-7
- EC Name:
- 2-(2-butoxyethoxy)ethyl 6-propylpiperonyl ether
- Cas Number:
- 51-03-6
- Molecular formula:
- C19H30O5
- IUPAC Name:
- 2-(2-butoxyethoxy)ethyl 6-propylpiperonyl ether
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24hours
- Doses:
- 2.0 g/kg
- No. of animals per sex per dose:
- 5 male and 5 female
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- No mortalities were observed during the test period.
- Clinical signs:
- other: Well defined erythema and very slight to slight edema were found after unwrapping at 24 hours after treatment. From day 3 onwards (one female after day 7) no clinical signs were visible any longer.
- Gross pathology:
- No gross abnormalities were observed in any of the animals necropsied 14 days after treatment.
Any other information on results incl. tables
No mortalities were observed during the test period. Very slight to well-defined erythema and very slight to slight edema were found after unwrapping at 24 hours after treatment. From day 2 onwards no clinical signs were visible any longer with the exeption of one female where irritation persisted until day 7. In addition no gross abnormalities were observed in any of the animals necropsied 14 days after treatment
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- Piperonyl butoxide is of low dermal acute toxicity. The dermal LD50 of Piperonyl Butoxide was determined to be greater than 2000 mg/kg b.w.
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