Registration Dossier
Registration Dossier
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EC number: 200-076-7 | CAS number: 51-03-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-(2-butoxyethoxy)ethyl 6-propylpiperonyl ether
- EC Number:
- 200-076-7
- EC Name:
- 2-(2-butoxyethoxy)ethyl 6-propylpiperonyl ether
- Cas Number:
- 51-03-6
- Molecular formula:
- C19H30O5
- IUPAC Name:
- 2-(2-butoxyethoxy)ethyl 6-propylpiperonyl ether
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- undiluted
Amount applied: 0.1 ml - Duration of treatment / exposure:
- 168 hour(s)
- Observation period (in vivo):
- 24hour
- Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.17
- Max. score:
- 0.33
- Reversibility:
- fully reversible
Any other information on results incl. tables
RS-Freetext:
AVERAGE SCORE
-Cornea: 0 at 1, 24, 48, 72 hours; 0 at 4 and 7 days.
-Iris: 0 at 1, 24, 48, 72 hours; 0 at 4 and 7 days.
-Conjunctivae: 6 at 1 hour, 2 at 24 hours, 1 at 48 hours, 1 at 48 hours, 0 at 72 hours, 0 at 4 and 7 days.
-Overall irritation score: 3.3 at 1 hours, 0.7 at 24 hours, 0.3 at 48 hours, 0
at 72 hours, 4 and 7 days.
Slight conjunctival redness (grade 1) were observed one hour after instillation. Within the first 24 hours the symptoms became milder (redness grade 1, at 2/6 animals). Within 48 hours the majority of the animals did not show effects any longer.
Within 72 hours all animals were free from irritation.
The cornea and iris were not affected at all
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test article, when instilled into the conjunctival sac as supplied, produced conjunctival irritation in 6/6 albino rabbit eyes. No conjunctival irritation was observed in any of the test animals by the 72 hour reading. No corneal opacity or iritis was noted during the observation period.
Piperonyl Butoxide does not classify as an eye irritant.
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