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REACH

1-(6-methoxy-2-naphthyl)ethan-1-one

EC number: 223-453-8 | CAS number: 3900-45-6

Life Cycle description
Uses advised against

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

The estimated lethal dose concentration of 1-(6-methoxy-2-naphthyl)ethan-1-one for Lepomis macrochirus for 96 hours using QSAR toolbox version 2.3 is 15.18 mg/l. But the BCF value of 1-(6-methoxy-2-naphthyl)ethan-1-one reported was not >= 2000 as well as the substance was found to be rapidly degradable.

Thus considering the CLP Criteria for aquatic classification of the substance, it is concluded that 1-(6-methoxy-2-naphthyl) ethan-1-one does not exhibit short term toxicity to fish

Key value for chemical safety assessment

Fresh water fish

Effect concentration:: 15.18 mg/L

Additional information

Based on the various studies available with Klimish rating 2 and 4 for the target substance CAS NO 39004506 and read across substances and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows

Sr.No	Endpoint	Effect values	Basis for effects	Duration	Species	Remarks
1	LC50	15.18299 mg/l	mortality	96 hrs	Lepomis macrochirus	Predicted data for target chemical
2	LC50	42.9921 mg/l	mortality	96 hrs	Oncorhynchus mykiss	Predicted data for target chemical
3	LC50	5.21 mg/l	mortality	96 hrs	Pimephales promelas	Data from DEPAof CAS NO 93-08-3
4	LC50	15.2 mg/l	mortality	48 hrs	Pimephales promelas	Data from study report for CAS NO 119-61-9
5	EC50	14.9 mg/l	mortality	24 hrs	Pimephales promelas	Data from study report for CAS NO 119-61-9

By applying weight of evidence approach to the studies summarized in the above table it can be observed that the LC50 values was found to be in range of 5.21 to42.9921mg/l in 96 hrs and 48 hrs and the EC50 value was found to be 14.9 mg/l in 24 hrs on the basis of mortality effect . But the BCF value of 1-(6-methoxy-2-naphthyl)ethan-1-one reported was not >= 2000 as well as the substance was found to be rapidly degradable. Thus considering the CLP Criteria for aquatic classification of the substance,, it is concluded that 1-(6-methoxy-2-naphthyl) ethan-1-one does not exhibit short term toxicity to fish (Lepomis macrochirus,Oncorhynchus mykiss and Pimephales promelas)

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