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EC number: 224-698-3 | CAS number: 4454-05-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
- Reference Type:
- publication
- Title:
- 3,4-Dihydro-2-methoxy-2H-pyran (CAS No. 4454-05-1)
- Author:
- OECD
- Year:
- 2 003
- Bibliographic source:
- cited in OECD SIDS 3,4-Dihydro-2-methoxy-2H-pyran for SIAM 16, 27-30 May 2003, Paris, France.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 3,4-dihydro-2-methoxy-2H-pyran
- EC Number:
- 224-698-3
- EC Name:
- 3,4-dihydro-2-methoxy-2H-pyran
- Cas Number:
- 4454-05-1
- Molecular formula:
- C6H10O2
- IUPAC Name:
- 2-methoxy-3,4-dihydro-2H-pyran
- Details on test material:
- - Name of test material (as cited in study report): Methoxydihydropyran
- Physical state: clear colourless liquid
- Analytical purity: ca. 95%
- Impurities (identity and concentrations): 4% dimer acrolein, traces of acrolein and methylvinylether
- Lot/batch No.: not reported
- Stability under test conditions: not reported
- Storage condition of test material: not reported
Constituent 1
- Specific details on test material used for the study:
- purity: ca. 95%
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: SPRA, Mus Rattus, Brunnthal
- Weight at study initiation: 185±15 g
- Diet: Herilan MRH, H . EGGERSMANN KG, ad libitum
- Water: Tap water, ad libitum
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
Exposure concentrations of the test substance were generated by pumping the liquid test substance at constant rates into glass vaporization flasks heated to 60°C, the vapors were mixed with fresh air and transmitted to the exposure chamber.
CHAMBER DESCRIPTION
- Exposure apparatus: Inhalation chamber made from glass and steel
- Exposure chamber volume: 200 l
TEST ATMOSPHERE
- Brief description of analytical method used: Gaschromatography (HP 5840A)
- Samples taken from breathing zone: yes - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- The measurement of nominal concentration of 12.0 mg/l was 6.1 mg/l.
- Duration of exposure:
- 4 h
- Concentrations:
- 6.1 mg/l
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: clinical signs daily, body weight before, 7 days after and at the end of the experiment.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- Statistical calculations were made using Binomial test after Wittig (Mathematische Statistik 1974, p 32 - 35).
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 6.1 mg/L air (analytical)
- Exp. duration:
- 4 h
- Mortality:
- No mortality was observed.
- Clinical signs:
- other: The signs observed were reddish watery nasal secretions, later reddish sticky eyes and nose, eyelid closure, intermitent respiration, staggering gait, ruffled and sticky fur coat. The signs were reversible within 8 days of observation period.
- Body weight:
- There was no difference in the body weight gain between the test animals and historical controls.
- Gross pathology:
- No alterations were observed.
Applicant's summary and conclusion
- Executive summary:
This study was conducted as limit test comparable to OECD guideline 403 and is reliable without restrictions. Ten males and ten females were exposed to vapors of the test substance at concentration of 6.1 mg/l (analytical). No mortality was observed. The signs observed were reddish watery nasal secretions, later reddish sticky eyes and nose, eyelid closure, intermitent respiration, staggering gait, ruffled and sticky fur coat. The signs were reversible within 8 days of observation period. There was no difference in the body weight gain between the test animals and historical controls. No alterations were observed at necropsy.
Conclusion: According to the test results, the LC50 of the test substance is >6.1 mg/l for male and female animals.
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