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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin sensitisation, other
Remarks:
in vivo test already available
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well documented study report which meets basic scientific principles.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Principles of method if other than guideline:
open epicutaneous test.
GLP compliance:
no
Type of study:
open epicutaneous test

Test material

Constituent 1
Chemical structure
Reference substance name:
3,4-dihydro-2-methoxy-2H-pyran
EC Number:
224-698-3
EC Name:
3,4-dihydro-2-methoxy-2H-pyran
Cas Number:
4454-05-1
Molecular formula:
C6H10O2
IUPAC Name:
2-methoxy-3,4-dihydro-2H-pyran
Details on test material:
- Name of test material (as cited in study report): Methoxydihydropyran
- Physical state: clear liquid
- Analytical purity: 99.5%
- Impurities (identity and concentrations): 0.5 % water

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
female

Results and discussion

In vivo (non-LLNA)

Resultsopen allclose all
Reading:
1st reading
Hours after challenge:
12
Group:
test chemical
Dose level:
100 %
No. with + reactions:
0
Total no. in group:
10
Clinical observations:
Yellow-brown substance residues at the application site
Remarks on result:
other: Reading: 1st reading. . Hours after challenge: 12.0. Group: test group. Dose level: 100 %. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: Yellow-brown substance residues at the application site.
Reading:
1st reading
Hours after challenge:
12
Group:
negative control
Dose level:
0 %
No. with + reactions:
0
Total no. in group:
3
Clinical observations:
Yellow-brown substance residues at the application site
Remarks on result:
other: Reading: 1st reading. . Hours after challenge: 12.0. Group: negative control. Dose level: 0 %. No with. + reactions: 0.0. Total no. in groups: 3.0. Clinical observations: Yellow-brown substance residues at the application site.

Any other information on results incl. tables

Induction results: Desquamation (strong 7/10, moderate 3/10) and moderate oedema (10/10) were seen after 10 inductions. Brownish substance residues at the application site were observed in all animals.
Challenge results: Yellow-brown substance residues at the application site were observed in both test and control groups. No other skin reactions were observed.

Applicant's summary and conclusion

Executive summary:

The study as open-epicutaneous test was conducted for testing skin sensitization from Methoxydihydropyran. The study is reliable with restrictions (concentration not reported). Induction was performed 10 times with undiluted test substance within 2 weeks. Challenge was performed 11 days after induction. Moderate to strong desquamation and moderate oedema was observed after induction. No skin reactions were observed after challenge both in test and challenge groups except presence of yellow-brown substance residues at the application site.

Conclusion: According to the test results, the test substance is not a skin sensitizer.