3,4-dihydro-2-methoxy-2H-pyran

Health surveillance data

Administrative data

Endpoint:

health surveillance data

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Meets national standard method (TRGS 402).

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2003

Report date:

2003

Materials and methods

Study type:

biological exposure monitoring

Endpoint addressed:

not applicable

Test guideline

Qualifier:

according to guideline

Guideline:

other: national standard methods (TRGS 402)

Principles of method if other than guideline:

The concentration of Methoxydihydropyran (MDP) was detected in the air while filling the MDP into the reaction vessel. The samples were collected from a distance of 0.5 m apart from the work place, immediately at the drum opening, and in the worker's respiration zone. Sampling was performed at an elevated ambient air temperature of 32°C.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

3,4-dihydro-2-methoxy-2H-pyran

EC Number:

224-698-3

EC Name:

3,4-dihydro-2-methoxy-2H-pyran

Cas Number:

4454-05-1

Molecular formula:

C6H10O2

IUPAC Name:

2-methoxy-3,4-dihydro-2H-pyran

Details on test material:

- Name of test material (as cited in study report): Methoxydihydropyran
- Analytical purity: not reported
- Lot/batch No.: not reported

Method

Type of population:

occupational

Details on study design:

Air monitoring was conducted during filling of methodydihydropyran (MDP) into the reaction vessel using personal air sampling. Additionally, stationary sampling was performed at a distance of 0.5 m apart from the work place, and immediately at the drum opening. Air samples were collected for 30 minutes. MDP was adsorbed to a test tube during sampling and desorped prior to analysis. Temparature of ambient air was 32°C. Sampling was not conducted during routine work procedure because this type of work, i.e. manual drum emptying, is only occassionally performed. Therefore, the work situation was imitated. However, work conditions during sampling differed in this study from routine work conditions in that the worker placed himself at the drum for the full 30 min sampling period, whereas in the normal work situation the worker remains only few minutes next to the drum when having started the pump for emptying the drum. The workers exposure periods may largely vary. Estimates range from 10 minutes to 5 hours on some days. Exposure periods per year are estimated to range between 2 and 120 hours per year. During the sampling the employee used the same standard of respiratory protection as it is used under normal work conditions.

Results and discussion

Results:

MDP was present in the worker's respiration zone at a concentration of 0.036 mg/l (8 ppm). At a distance of 0.5 m, the concentration of MDP in air was 0.012 mg/l (2 ppm). Directly above the drum opening, the concentration of MDP exceeded 0.77 mg/l. Manual emptying of drums using pumps is occasionally performed at some of the producer's sites. This exposure situation was mimicked in order to perform air monitoring. Sampling was performed at an elevated ambient air temperature of 32°C. Therefore it was concluded that the measured concentrations represent worst-case conditions.

Any other information on results incl. tables

	Sample 1	Sample 2	Sample 3
Sampling type	personal	stationary	stationary
Sampling duration	30 min	30 min	30 min
Sampling volume	0.163 L	0.159 L	0.159 L
Concentration detected	0.036 mg/l	0.012 mg/l	0.77 mg/l

Sample 1: in the worker's respiration zone

Sample 2: at a distance of 0.5 m apart from the work place

Sample 3: directly above the drum opening

Applicant's summary and conclusion

Executive summary:

This study was performed according to national standard method (TRGS 402) and is reliable without restrictions. Air monitoring was conducted during filling of methodydihydropyran (MDP) into the reaction vessel using personal air sampling. Additionally, stationary sampling was performed at a distance of 0.5 m apart from the work place, and immediately at the drum opening. Annual workers exposure periods per year were estimated to range between 2 and 120 hours. The concentrations of MDP present in the worker's respiration zone, at a distance of 0.5 m and directly above the drum were 0.036, 0.012 and 0.77 mg/l, respectively.

Conclusion: The concentration of MDP in the breathing zone was 8 ppm. The exposure is however low because standard personal protective equipment to be used does include respiratory protection.