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Diss Factsheets
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EC number: 224-698-3 | CAS number: 4454-05-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Meets national standard method (TRGS 402).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
- Study type:
- biological exposure monitoring
- Endpoint addressed:
- not applicable
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: national standard methods (TRGS 402)
- Principles of method if other than guideline:
- The concentration of Methoxydihydropyran (MDP) was detected in the air while filling the MDP into the reaction vessel. The samples were collected from a distance of 0.5 m apart from the work place, immediately at the drum opening, and in the worker's respiration zone. Sampling was performed at an elevated ambient air temperature of 32°C.
- GLP compliance:
- no
Test material
- Reference substance name:
- 3,4-dihydro-2-methoxy-2H-pyran
- EC Number:
- 224-698-3
- EC Name:
- 3,4-dihydro-2-methoxy-2H-pyran
- Cas Number:
- 4454-05-1
- Molecular formula:
- C6H10O2
- IUPAC Name:
- 2-methoxy-3,4-dihydro-2H-pyran
- Details on test material:
- - Name of test material (as cited in study report): Methoxydihydropyran
- Analytical purity: not reported
- Lot/batch No.: not reported
Constituent 1
Method
- Type of population:
- occupational
- Details on study design:
- Air monitoring was conducted during filling of methodydihydropyran (MDP) into the reaction vessel using personal air sampling. Additionally, stationary sampling was performed at a distance of 0.5 m apart from the work place, and immediately at the drum opening. Air samples were collected for 30 minutes. MDP was adsorbed to a test tube during sampling and desorped prior to analysis. Temparature of ambient air was 32°C. Sampling was not conducted during routine work procedure because this type of work, i.e. manual drum emptying, is only occassionally performed. Therefore, the work situation was imitated. However, work conditions during sampling differed in this study from routine work conditions in that the worker placed himself at the drum for the full 30 min sampling period, whereas in the normal work situation the worker remains only few minutes next to the drum when having started the pump for emptying the drum. The workers exposure periods may largely vary. Estimates range from 10 minutes to 5 hours on some days. Exposure periods per year are estimated to range between 2 and 120 hours per year. During the sampling the employee used the same standard of respiratory protection as it is used under normal work conditions.
Results and discussion
- Results:
- MDP was present in the worker's respiration zone at a concentration of 0.036 mg/l (8 ppm). At a distance of 0.5 m, the concentration of MDP in air was 0.012 mg/l (2 ppm). Directly above the drum opening, the concentration of MDP exceeded 0.77 mg/l. Manual emptying of drums using pumps is occasionally performed at some of the producer's sites. This exposure situation was mimicked in order to perform air monitoring. Sampling was performed at an elevated ambient air temperature of 32°C. Therefore it was concluded that the measured concentrations represent worst-case conditions.
Any other information on results incl. tables
Sample 1 |
Sample 2 |
Sample 3 |
|
Sampling type |
personal |
stationary |
stationary |
Sampling duration |
30 min |
30 min |
30 min |
Sampling volume |
0.163 L |
0.159 L |
0.159 L |
Concentration detected |
0.036 mg/l |
0.012 mg/l |
0.77 mg/l |
Sample 1: in the worker's respiration zone
Sample 2: at a distance of 0.5 m apart from the work place
Sample 3: directly above the drum opening
Applicant's summary and conclusion
- Executive summary:
This study was performed according to national standard method (TRGS 402) and is reliable without restrictions. Air monitoring was conducted during filling of methodydihydropyran (MDP) into the reaction vessel using personal air sampling. Additionally, stationary sampling was performed at a distance of 0.5 m apart from the work place, and immediately at the drum opening. Annual workers exposure periods per year were estimated to range between 2 and 120 hours. The concentrations of MDP present in the worker's respiration zone, at a distance of 0.5 m and directly above the drum were 0.036, 0.012 and 0.77 mg/l, respectively.
Conclusion: The concentration of MDP in the breathing zone was 8 ppm. The exposure is however low because standard personal protective equipment to be used does include respiratory protection.
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