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EC number: 231-512-4 | CAS number: 7601-90-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
A two-generation study was conducted in rats exposed to ammonium perchlorate at 0, 0.3, 3 and 30 mg/kg/day.
Parental and offspring NOAEL were set at 0.3 mg/kg/day because of thyroid hypertrophy/hyperplasia. This effect was already identified in the 90 days study and the presence of the effect on the offspring is not a specific reproductive toxic effect.
Fertility NOAEL was set at 30 mg/kg/day as there was no effect on reproductive parameters at highest dose used in this study.
Perchloric acid, once absorbed in the general circulation is expected to be transformed into perchlorate moiety because of the blood buffering effect. Therefore the results of this study on ammonium perchlorate are used in a read across approach to evaluate perchloric acid reproductive toxicity.
Short description of key information:
- Perchloric acid reproductive toxicity evaluated by read-across with ammonium perchlorate.
- Rat thyroid hypertrophy/hyperplasia observed at the same dose-level on both parents and offspring with no specific toxicity on offsprings when treated orally with ammonium perchlorate.
- No effects observed on the reproductive parameters at the highest studied dose 30 mg/kg/day.
Effects on developmental toxicity
Description of key information
- Perchloric acid developmental toxicity evaluated by read-across with ammonium perchlorate.
- Thyroid hypertrophy/hyperplasia observed on rat dams when treated orally with ammonium perchlorate.
- No adverse effects observed on the rat litters at the highest studied dose 30 mg/kg/day.
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Ammonium perchlorate was provided to groups of 24 female rats via drinking water, at dose-levels of 0 (control), 0.01, 0.1, 1 and 30 mg/kg/day before (2 weeks before mating, complete mating) and during gestation (21 days).
At 30 mg/kg/day, there was no maternal toxicity. Pre- and Post-implantation loss indices were higher than in controls but this was not considered to represent relevant resorptions when considering the number of resorptions, implantation sites, live and dead foetuses. There was a minor indication of delayed ossification (fewer ossification sites) but this effect is minimal, and not adverse: it represents a slight delay in development which is usually reversible. No developmental abnormalities were observed. At 0.01 to 1 mg/kg/day, neither maternal nor embryo-/foeto- or developmental toxicities were observed.
An additional 16 litters/group were sacrificed on DG 21 for thyroid histopathology and thyroid hormones measurement. As expected, effects on thyroid hormones and colloid depletion were observed in both dams and foetuses but are considered as adaptative and non adverse. However, thyroid follicular cells hypertrophy/hyperplasia was observed only for the dams at 30 mg/kg/day.
Therefore with a maternal NOAEL at 1.0 mg/kg-day and a developmental NOAEL at 30.0 mg/kg-day ammonium perchlorate is not a selective developmental toxicant.
Perchloric acid, once absorbed in the general circulation is expected to be transformed into perchlorate moiety because of the blood buffering effect. Therefore the results of this study on ammonium perchlorate are used in a read across approach to evaluate perchloric acid developmental toxicity.
Justification for classification or non-classification
In the available reproductive and developmental studies on Ammonium perchlorate no specific effects on fertility or on development have been identified.
Based on these results Perchloric acid is not classified for fertility and developmental toxicity according to DSD 67/548/EC and to CLP 1272/2008/EC criteria.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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