Registration Dossier
Registration Dossier
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EC number: 248-704-9 | CAS number: 27871-49-4
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010-05-31 to 2010-09-03
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Version / remarks:
- adopted May 31, 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- adopted April 13, 2004
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- - Name of the test material used in the report: PURASOLV® ML
- CAS Number: 27871-49-4
- Appearance: Clear, colourless liquid
- Batch no.: 2010-03-22
- Purity: 99.03%
- Storage: At room temperature in the dark under nitrogen
- Expiry date: 2011-03-19 - Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- -0.2
- Temp.:
- 20 °C
- pH:
- ca. 7
- Conclusions:
- The log Kow of methyl (S)-lactate is -0.2 at 20 °C.
- Executive summary:
In a GLP study conducted according to OECD 117, the octanol/water partition coefficient of methyl (S)-lactate was determined by using the HPLC method. The log Kow of methyl (S)-lactate is -0.2 at 20 °C (Kow: 0.58).
Reference
Calculation of the Pow:
The Pow of the test substance was calculated to be 6.6 x
10^-1 (log
Pow -0.18) using the Rekker calculation method.
HPLC Method:
HPLC chromatograms of the test substance
solution, corresponding blank solutions and calibration curves are
provided in the original report.
The equation of the regression line was: log
k'= 0.584 x log
Pow - 0.551 (r= 0.9990, n= 12)
Since the result of the HPLC method matched
very well with the Rekker calculation method, the result is considered
to be accurate, despite the fact that the value was slightly
extrapolated.
Description of key information
In a GLP study conducted according to OECD 117, the log Pow of methyl (S)-lactate was determined to be -0.2 (Pow: 0.58).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -0.2
- at the temperature of:
- 20 °C
Additional information
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