Registration Dossier
Registration Dossier
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EC number: 210-155-8 | CAS number: 608-25-3
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Title:
- Unnamed
- Year:
- 2 008
Materials and methods
Test guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- 2-methylresorcinol
- EC Number:
- 210-155-8
- EC Name:
- 2-methylresorcinol
- Cas Number:
- 608-25-3
- Molecular formula:
- C7H8O2
- IUPAC Name:
- 2-methylbenzene-1,3-diol
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
Study design: in vivo (LLNA)
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- 25 microliter 0% (vehicle control), 1%, 10%, 25%, 50%
- No. of animals per dose:
- 5
- Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- EC3
- Value:
- 50
- Remarks on result:
- other: see any other information on results including tables
- Parameter:
- SI
- Value:
- 0.7
- Test group / Remarks:
- 5
- Remarks on result:
- other: concentration 1%
- Parameter:
- SI
- Value:
- 0.6
- Test group / Remarks:
- 5
- Remarks on result:
- other: concentration 10%
- Parameter:
- SI
- Value:
- 1.1
- Test group / Remarks:
- 5
- Remarks on result:
- other: concentration 25%
- Parameter:
- SI
- Value:
- 3
- Test group / Remarks:
- 5
- Remarks on result:
- other: concentration 50%
Any other information on results incl. tables
The individual findings are summarized in the following table:
Test Item Concentration S.I.
1% (w/v) 0.7
10% (w/v) 0.6
25% (w/v) 1.1
50% (w/v) 3.0
The EC 3 value was determined to be 50%.
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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