Registration Dossier
Registration Dossier
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EC number: 274-764-0 | CAS number: 70693-32-2
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (3 h): ≥ 1000 mg/L for the respiration of activated sludge microorganisms (OECD 209); read-across
Key value for chemical safety assessment
Additional information
No data are available on the toxicity of Decanoic acid, mixed esters with neopentyl glycol and octanoic acid (CAS No. 70693-32-2) to microorganisms. The assessment of toxicity to microorganisms was, therefore, based on a study conducted with the structurally similar category member Heptanoic acid, ester with 2,2-dimethyl-1,3-propanediol (CAS No. 68855-18-5). This read across approach is in accordance with Regulation (EC) No 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach. Further justification is given within the endpoint summary 6.1 and within the category justification in Section 13.
The key study conducted with Heptanoic acid, ester with 2,2-dimethyl-1,3-propanediol (CAS No. 68855-18-5) was performed according to OECD Guideline 209 and GLP (Roulstone, 2012). Activated sludge of a predominantly domestic sewage was exposed to the test substance during 3 hours, at nominal concentrations of 0, 10, 100 and 1000 mg/L. No effect on the respiration of activated sludge was observed, and the NOEC was reported to be ≥ 1000 mg/L.
Thus, based on theabove mentioned result, and due to the structural and profile similarities of the substances, as are explained with in the overall endpoint summary 6.1 it can be concluded that no effects on activated sludge microorganisms are expected up tothe limit ofwater solubility for Decanoic acid, mixed esters with neopentyl glycol and octanoic acid. As it can be seen in the data matrix of the category justification in section 13 and the overall endpoint summary IUCLID 6.1, all reliable data in the category support the hazard assessment of each category member by showing a consistent pattern of results.
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