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Diss Factsheets
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EC number: 914-103-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
- Based
on the available information on absorption, distribution, metabolism and
excretion properties as well as the available toxicological data of all
three components of the reaction mass, it can be concluded, that ammonium
sulphate is the most critical substance within the reaction mass. There
is, however, no information available on the skin sensitising potential of
ammonium sulphate. Thus, read-across is conducted from the structurally
related substance ammonium chloride (CAS 12125-02-9) based on an analogue
approach (a detailed justification for the analogue approach is provided
as attachment in IUCLID Section 13).
The
skin sensitisation potential of ammonium chloride was evaluated in a study
performed according to GLP and guideline EPA 540/9-82-025 (Hoechst, 1987).
Twenty Pirbright-White guinea pigs received an intracutaneous induction
with 5% ammonium sulphate. 8 days later, a second induction with a
concentration of 25% by an occlusive epicutaneous application which was
held in place for 48 h was performed. Eleven days after the second
induction, the animals were challenged by an application of 0.5 mL of an
aqueous solution containing 10% ammonium sulphate under occlusive
conditions for 24 h. The readings 24 and 48 h after removal of the
occlusive dressing revealed that 2 of 20 animals showed very slight,
hardly perceptible erythema. Thus, the criterion for a positive test
result (positive reactions in 30% of animals) is not fulfilled. Therefore,
ammonium chloride can be regarded as not sensitising to skin.
Migrated from Short description of key information:
Based on the read-across data from ammonium chloride (CAS 12125-02-9), the reaction mass of ammonium sulphate and potassium sulfate and sodium sulphate is expected to be not skin sensitising.
Justification for classification or non-classification
Based on read-across, the available data on the skin sensitising potential of the reaction mass of ammonium sulphate and potassium sulfate and sodium sulphate are conclusive but not sufficient for classification according to the criteria of Directive 67/548/EEC (DSD) and Regulation 1272/2008/EC (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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