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Diss Factsheets
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EC number: 914-103-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Limited documentation, no information on purity.
Data source
Reference
- Reference Type:
- publication
- Title:
- Controlled Exposures Of Human Volunteers To Sulfate Aerosols. Health Effects And Aerosol Characterization.
- Author:
- Avol EL et al
- Year:
- 1 979
- Bibliographic source:
- Am Rev Respiratory Disease 120: 319-327.
Materials and methods
- Type of study / information:
- controlled study
- Endpoint addressed:
- acute toxicity: inhalation
- Principles of method if other than guideline:
- Both healthy and asthmatic adult men were exposed for a 2 h period to ammonium sulphate under controlled conditions (particle size distribution and concentration). Lung function tests were performed.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ammonium sulphate
- EC Number:
- 231-984-1
- EC Name:
- Ammonium sulphate
- Cas Number:
- 7783-20-2
- Molecular formula:
- H8N2O4S
- IUPAC Name:
- diammonium sulfate
- Details on test material:
- - Name of test material (as cited in study report): ammonium sulphate
No further data
Constituent 1
Method
- Exposure assessment:
- measured
Results and discussion
- Results:
- No evidence of an adverse health effect on healthy, sensitive and asthmatic adult men was found after 2-hour multiple day exposures to "worst case" ambient concentrations (0.1 to 0.3 mg/m³ of ammonium sulphate with a MMAD of 0.3-0.6 µm and a relative humidity ranging between 40 and 85% in the different experiments).
Any other information on results incl. tables
Five normal
subjects, 5 sensitive subjects and 6 asthmatics were studied.
Neither significant functional changes nor consistent changes in symptom
score were found in the normal group at low humidity. At high humidity,
significant variation in forced expiratory measures was detected, but
the changes were small in magnitude, and the performance tended to be
better on exposure days than on control days.
The sensitive group displayed small but significant variations in
pulmonary function at both low and high humidity; once again, these
appeared to be occurrences not related to the aerosols. On the last
exposure day of the high-humidity studies, the sensitive subjects
reported a significant increase in total symptom score. Examination of
the individual symptoms reports indicated that his was due to increased
fatigue.
The asthmatic subjects showed a marginal decrease in the slope of the
alveolar plateau of the single breath N2 washout between the beginning
and the end of exposure, both with clean air and with exposure to
ammonium sulphate. In the absence of other changes in function, this
would be interpreted as representing an increase in uniformity of
ventilation distribution within the bungs, i.e., an improvement in
function. Symptom scores and other pulmonary function results did not
indicate any increase toward dysfunction.
For details, see attached files, tables 2 and 3
Conclusion
In
conclusion, no evidence of an adverse health effect on healthy,
sensitive and asthmatic adult men was found after 2 -hour multiple day
exposures to "worst
case" ambient concentrations (0.1 to 0.3 mg/m³ of ammonium sulphate with
a MMAD of 0.3-0.6 µm and a relative humidity ranging between 40 and 85%
in the different experiments).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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