Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: 92/69/EWG, B.1 (modif.); OECD 401 Siehe Bemerkung
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test animals

Species:
other: rat, Sprague-Dawley

Administration / exposure

Vehicle:
other: Maisöl "ENGLISH" Corn oil.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
>= 2 000 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 1
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 1
Clinical signs:
Signs of toxicity related to dose levels:
Verstorbene Tiere (1M und 1W):

Urämie, verminderte Aktivität, Diarrhöe, Atembeschwerden,
verfärbter/wunder Genitalbereich, unsicherer Gang, urinale
Inkontinenz.

Überlebende Tiere (4M und 4W):

Gewichtszunahme.

"ENGLISH"

Animals which died during the study (1M and 1W):

Apparent blood inthe urine, decreased activity,

diarrhea, labored breathing, staining/scores in the

genital area, an unsteady gait and apparent urinary
incontinence.
Gross pathology:
Effects on organs:
Verstorbene Tiere (1M und 1W):

Intestinale Verfärbung mit rotem Inhalt, vergrößerte Nieren,
hellrote Lungen, weißer Pankreas, verkleinerte Milz,
rot-weiß gefleckte Magenschleimhaut.

Überlebende Tiere (terminale Nekropsie):

Keine Veränderungen der inneren Organe.

"ENGLISH"

Animals which died during the study (1M and 1W):

red intestines that contained a red substance,

enlarged kidneys, bright red lungs, a white pancreas,

a small spleen and red/white areas on the stomach mucosa.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU