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EC number: 443-050-2 | CAS number: 120903-40-4 PERFLUOROHEXANE NITRILE VINYL ETHER
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The acute toxicity of MV5CN was evaluated in a single study in rats. The result of the study was:
Rat oral LD50 > 2000 mg/kg when tested according to OECD 423.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Version / remarks:
- 1996
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- 1996
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source (i.e. manufacturer or supplier) and lot/batch number of test material: 3M Company, Lot 3
- Purity, including information on contaminants, isomers, etc.: 93.8%
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: refrigerator (approx. 2-8C), light protected, under nitrogen
- Stability and homogeneity of the test material in the vehicle/solvent under test conditions (e.g. in the exposure medium) and during storage: No data
- Stability in the medium, i.e. sensitivity of the test material to hydrolysis and/or photolysis: No data
- Solubility and stability of the test material in the solvent/vehicle and the exposure medium: No data
- Reactivity of the test material with the incubation material used (e.g. plastic ware): No data
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing (e.g. warming, grinding): Not applicable
- Preliminary purification step (if any): No data
- Final concentration of a dissolved solid, stock liquid or gel: No data
- Final preparation of a solid (e.g. stock crystals ground to fine powder using a mortar and pestle): Not applicable
FORM AS APPLIED IN THE TEST (if different from that of starting material) : unchanged test substance
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Rationale for alternative/additional species to rat (if applicable) : not applicable
- Source: Harlon Winkelmann GmbH, Gartenstrasse 27, D33178 Borchen
- Females (if applicable) nulliparous and non-pregnant: yes
- Rationale for use of males (if applicable) : No data
- Age at study initiation: 6-10 weeks
- Weight at study initiation: males: mean 239 g; females: mean 193 g
- Fasting period before study: No data
- Housing: 3 animals per cage
- Historical data: kept by lab
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: at least 5 days
- Microbiological status when known : No data
- Method of randomisation in assigning animals to test and control groups: computer generated algorithm
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22C
- Humidity (%): 50%
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): 12 hours light/dark cycle
IN-LIFE DATES: From: 15 May 2001 To: 30 May 2001 - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: No vehicle
- Amount of vehicle (if gavage): No vehicle
- Justification for choice of vehicle: No vehicle
- Lot/batch no. (if required): No vehicle
- Purity: No vehicle
MAXIMUM DOSE VOLUME APPLIED:No data
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical observations were recorded twice per day and body weights recorded weekly
- Necropsy of survivors performed: yes
- Clinical signs including body weight: Clinical observations were recorded twice per day and body weights recorded weekly
- Other examinations performed: clinical signs, body weight, gross necropsy - Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occurred during the study.
- Clinical signs:
- other: Immediately after administration the male and female animals showed flanks drawn in and irregular respiration. In addition, panting was observed in one female animal. All clinical signs had completely disappeared 2 to 4 hours after adminstration in males
- Gross pathology:
- The animals killed at the end of the observation period showed no macroscopically visible changes.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 of perfluorohexane nitrile vinyl ether for male and female rats is greater than 2000 mg/kg bw.
- Executive summary:
MV5CN was assessed for acute toxicity in a GLP-compliant, OECD 423 study. Rats (3/sex) were administered the test substance via oral gavage at 2000 mg/kg bw. The animals were observed for 14 days post dose and clinical signs (twice daily) and body weights (weekly) were recorded. No mortality occurred. No changes to body weight or macroscopic changes were observed. Immediately after administration all animals showed flanks drawn in and irregular respiration. In addition, panting was observed in one female animal. All clinical signs had completely disappeared 2 to 4 hours after adminstration in males or 4 to 8 hours after administration in females. The LD50 of MV5CN rats is greater than 2000 mg/kg bw.
Reference
Additional information
Justification for classification or non-classification
Based on the result of the study, MV5CN is not classified for acute oral toxicity.
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