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EC number: 443-050-2 | CAS number: 120903-40-4 PERFLUOROHEXANE NITRILE VINYL ETHER
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
48 hour EC50=0.033 mg/L (geometric mean) in Daphnia magna (OECD 202) for MV5CN amide
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- 0.033 mg/L
Additional information
MV5CN s is both volatile and hydrolytically unstable. As such, to
the extent that the test material remains in water the effects are due
to the hydrolysis product. Thus, the key study was conducted using the
hydrolysis product. MV5CN amide is the hydrolysis product of MV5CN. The 48 hour EC50 of MV5CN amide to Daphnia magna was determined in test according to OECD 202 guidelines. Test concentrations of 0.22, 0.46, 1.0, 2.2, 4.6 and 10% were used, diluted from the saturated solution made at a 100 mg/L loading rate. Measured geometric mean concentrations were 0.0089, 0.019, 0.042, 0.091, 0.20 and 0.42 mg/L. The test was run using 5 animals per vessel with 4 replicates and 5 animals per vessel with one replicate for the blank control. No dispersant was used. Test vessels were closed and without headspace. A 48hr EC50=0.033 was reported based on geometric mean concentrations. At the end of the test, a dose-related increase was observed at 1.0% of the loading rate, reaching 100% immobilization at the three highest test concentrations. Study was conducted under international guidelines and was compliant with GLP criteria. The test is therefore considered reliable without restrictions. The result is considered suitable for use in Risk Assessment, Classification & Labeling, and PBT analysis.
Two additional studies were run on the parent material. In the first
study, the test substance could not be detected during test solution
mixing. In the second test, analytical was conducted thought the assay,
and at no point could the matertial be detected. Due to the hydrolystic
instability, volatility, and lack of detectable material in the test
solutions, these test were not considered sutiable for Risk
Assessment, Classification & Labeling, nor PBT analysis.
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