Registration Dossier
Registration Dossier
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EC number: 610-200-5 | CAS number: 446292-07-5
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- 1H-Isoindole-1,3(2H)-dione, 2-[(2R)-2-hydroxy-3-[[4-(3-oxo-4-morpholinyl)phenyl]amino]propyl]-
- IUPAC Name:
- 1H-Isoindole-1,3(2H)-dione, 2-[(2R)-2-hydroxy-3-[[4-(3-oxo-4-morpholinyl)phenyl]amino]propyl]-
- Reference substance name:
- 2-[(2R)-2-hydroxy-3-{[4-(3-oxomorpholin-4-yl)phenyl]amino}propyl]-1H-isoindole-1,3(2H)-dione
- EC Number:
- 610-200-5
- Cas Number:
- 446292-07-5
- Molecular formula:
- C21 H21 N3 O5
- IUPAC Name:
- 2-[(2R)-2-hydroxy-3-{[4-(3-oxomorpholin-4-yl)phenyl]amino}propyl]-1H-isoindole-1,3(2H)-dione
Constituent 1
Constituent 2
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Partition coefficient:
- 0.6
- Temp.:
- 25 °C
- pH:
- 7.2
- Details on results:
- The test and calibration items were dissolved in acetonitrile. The concentration for the calibration item was ca. 0.05 to 0.16 mg/mL. The concentration for the test item was ca. 0.035 mg/mL.
Applicant's summary and conclusion
- Conclusions:
- Hydroxyaminophthalimid has a log P of 0.6 at 25°C and a pH value of 7.2.
- Executive summary:
Hydroxyaminophthalimid has a log P of 0.6 at 25°C and a pH value of 7.2.
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