Registration Dossier
Registration Dossier
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EC number: 685-618-4 | CAS number: 35194-30-0
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Test dates: February 01 to 12, 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- The study was conducted according to an internationally recognised method, and under GLP. The substance is adequately identified. Therefore full validation applies.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- GIPC; effective 16 March 2007 (validity 18 months)
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- Storage conditions of test material: Stored at room temperature protected from direct sun light.
- Analytical method:
- gas chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 3.06
- Temp.:
- 20 °C
- pH:
- 6.19
- Conclusions:
- The substance has low potential to bioaccumulate in the environment, according to CLP classification criteria for aquatic chronic toxicity (log Kow <4).
- Executive summary:
The partition coefficient of the test substance was determined under GLP according to EU A.8 guideline, shake flask method.
Determinations were conducted in duplicate for three solvents ratio (1:10, 2:10, 1:20, 2 replicates each), concentrations were measured using a GC-FID validated method. Individual results fulfilled the validity criteria for reproducibility, and mass balance was satisfactory, so the average value is retained.
The log Pow was determined to be 3.06 (at 20 °C and pH=6.2).
Reference
| ratio | 1:10 | 2:10 | 1:20 | |||
| replicate vessel | 1 | 2 | 1 | 2 | 1 | 2 |
| log Kow | 3,07 | 3,06 | 3,06 | 3,09 | 3,04 | 3,02 |
| mass balance | 107,2% | 106,8% | 106,3% | 108,5% | 106,7% | 106,0% |
Mean Log Pow and SD = 3.06 +/-0.02
The validity criteria were fulfilled: The six LogPow values fell within a range of ± 0.3 units.
The pH of the water phase was measured as 6.19.
Description of key information
The data is relevant for classification in aquatic chronic toxicity hazard class, according to CLP criteria.
The substance has low potential for bioaccumulation (log Kow<4).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 3.06
- at the temperature of:
- 20 °C
Additional information
A fully reliable experimental study, conducted according to a recognized EC method and under GLP, is available.
It is considered as a key study, and the result is retained as key data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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