Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 613-915-0 | CAS number: 66233-43-0
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 Jan to 09 Aug 2016
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Deviations:
- not applicable
- GLP compliance:
- no
- Other quality assurance:
- ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
- Type of method:
- thermal analysis
- Remarks:
- Differential Thermal Analysis (DTA)
- Key result
- Melting / freezing pt.:
- 125.7 °C
- Remarks on result:
- other: atmospheric pressure was not reported
- Conclusions:
- The melting temperature of the substance was 125.7 °C.
- Executive summary:
According to the OECD Guideline 102, which conforms to test method A.1 (section 1.4.4) „Melting/Freezing temperature“ described in the EC-Guideline. Between approx. 45 °C – 75 °C an endothermic phase could be detected. This endothermic phase could be a glass transition. The melting temperature of the substance was 125.7 °C. The substance recrystallized after the melting process. A second heating could reproduce the melting point.
Reference
mean of five determinations, twice in an open and trice in a closed crucible.
Validity criteria for the measurement of the melting point:
| Target condition according to guideline: | Actual condition according to the study: | Validity criteria met: |
| The heating rate should not exceed 2 K/min. | Heating rate 1 K/min. | Yes |
| The mean of at least two measurements which are in the range of the estimated accuracy is reported as the melting temperature. | Five values were determined, each in closed and open crucible. | Yes |
| If the substance decomposes or sublimes before the melting temperature is reached, the temperature at which the effect is observed shall be reported. | The test substance was heated up to a temperature of 150°C - no thermal decomposition was observed. | Yes |
Description of key information
The melting temperature of DELTA-9(11)-Fluocortolon-Valerat was 125.7 °C. No pressure was reported.
Key value for chemical safety assessment
- Melting / freezing point at 101 325 Pa:
- 125.7 °C
Additional information
Between approx. 45 °C – 75 °C an endothermic phase could be detected. This endothermic phase could be a glass transition.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
