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EC number: 876-151-9 | CAS number: 2292123-68-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Radiolabelling:
- no
- Test temperature:
- 25 +/- 1°C
- Details on study design: HPLC method:
- Performance: The test item is in its undissociated form in the pH range 3 to 9 and accordingly the test was performed using the buffer solution at pH7 as an eluent.
Measurement conditions:
Instrument: HPLC with built-in UV Vis spectrophotometer.
Software: LabSolutions CS (Shimadzu.
Column: Inertsil CN-3 (150 mm x 2.1 mm I.D., particle size 5 µm, GL Sciences)
Column temperature: 25°C
Eluent: Methanol/buffer solution (pH 7) [10 mmol/L potassium dihydrogen phosphate solution adjusted to pH 7 with 1 mol/L sodium hydroxide solution] (6/4 v/v)
Flow rate: 0.2 mL/min
Measurement wavelength: Reference item 210 nm, test item and solvent blank 260 nm
Injection volume: 2 µL
Test temperature: 25 +/- 1°C
Reference substances: Formamide (for dead time: t0, 200.9 mg), N,N-Dimethylbenzamide (10.3 mg), atrazine (10 mg), linuron (2.3 mg), 1,2,3-trichlorobenzene (10.3 mg), phenanthrene (10 mg), and DDT (10.3 mg). Methanol was used as the solvent with all reference substances.
Preparation of test solutions: The test sample (10.3 mg) was weighed with an electronic balance and then filled up 25 mL with methanol by ultrasonic irradiation. This solution (1 mL) was filled up to 10 mL with the eluent and the solution was used as a solvent blank.
Measurement of retention times for reference items, and making of regression line: The reference item solution was injected twice to the test equipment and the retention times of reference items were measured. The capacity factors (K) of reference items were calculated. A regression line was made by the method of least squares using the adsorption coefficient (logKoc) and the logarithmic values of the capacity factors for reference items. The capacity factor (K), teh slope of regression equation (a) and the intercept of regression equation (b) were rounded to three decimal places.
K = (tR - t0)/t0
tR: Retention time of reference item (min)
t0: Dead time (min) (average of two measurements)
Log Koc = a x log K + b
a: Slope of regression equation
b: Intercept of regression equation
Measurement of retention time for test item: The test item solution was injected twice to the test equipment and the retention time of test item was measured. The solvent blank was injected once to the test equipment. It was confirmed that no peak existed at the peak position of test item by analysis of solvent blank.
Injection order: Reference item solution (first time), Test item solution (first time), test item solution (second time), solvent blank, reference item solution (second time).
Calculation of adsorption coefficient: The adsorption coefficient of test item was not calculated using the regression equation of regression line, because the retention time of test item was longer than DDT (Log Koc = 5.63). Therefore, the Log Koc was regarded as > 5.63. - Sample No.:
- #1
- Type:
- log Koc
- Value:
- > 5.63 dimensionless
- pH:
- 7
- Temp.:
- 25 °C
- Matrix:
- Methanol used as solvent
- Details on results (HPLC method):
- See Table in 'Any other information on results incl tables.' section for details.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The duplicate retention times of the test item and reference items were almost identical in all cases. Therefore, the results are judged to be valid. The Log Koc value was determined to be greater than the highest reference substance (> 5.63 at 25°C).
Reference
Calculation table for adsorption coefficient by HPLC Method
| tR | K | Log K | Log Koc | |
Reference item | Formamide (1) | 2.22 | t0 =2.23 | ||
Formamide (2) | 2.23 | ||||
N,N-Dimethylbenzamide (1) | 2.51 | 0.128 | -0.892 | 1.52 | |
N,N-Dimethylbenzamide (2) | 2.51 | 0.128 | -0.892 | 1.52 | |
Atrazine (1) | 2.85 | 0.281 | -0.551 | 1.81 | |
Atrazine (2) | 2.86 | 0.285 | -0.545 | 1.81 | |
Linuron (1) | 3.70 | 0.663 | -0.179 | 2.59 | |
Linuron (2) | 3.71 | 0.667 | -0.176 | 2.59 | |
1,2,3-Trichlorobenzene (1) | 4.46 | 1.004 | 0.002 | 3.16 | |
1,2,3-Trichlorobenzene (2) | 4.47 | 1.009 | 0.004 | 3.16 | |
Phenanthrene (1) | 6.98 | 2.137 | 0.330 | 4.09 | |
Phenanthrene (2) | 6.99 | 2.142 | 0.331 | 4.09 | |
DDT (1) | 11.04 | 3.962 | 0.598 | 5.63 | |
DDT (2) | 11.06 | 3.971 | 0.599 | 5.63 | |
Test item | A | 12.70 | - | - | > 5.63 |
B | 12.69 | - | - | > 5.63 | |
(A, B: Individual measurement) | Average | > 5.63 |
Log Koc = 2.684 x log K + 3.440
r = 0.962
Description of key information
An OECD 121 study is available on the substance. As the value was screened as > 5.63 (greater than the highest reference substance value) no key value for chemical safety assessment is included.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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