4-[(2E)-3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-2-enoyl]-N-[(4R)-2-ethyl-3-oxo-1,2-oxazolidin-4-yl]-2-methylbenzamide

Vapour pressure

Administrative data

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2019

Report date:

2019

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

March 2006

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

gas saturation method

Test material

Test material information

Constituent 1

Reference substance name:

4-[3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-2-enoyl]-N-(2-ethyl-3-oxo-1,2-oxazolidin-4-yl)-2-methylbenzamide

Molecular formula:

C23H18Cl2F4N2O4

IUPAC Name:

4-[3-(3,5-dichloro-4-fluorophenyl)-4,4,4-trifluorobut-2-enoyl]-N-(2-ethyl-3-oxo-1,2-oxazolidin-4-yl)-2-methylbenzamide

Test material form:

solid

Details on test material:

Off-white

Results and discussion

Vapour pressure

Vapour pressure 1

Key result

Test no.:

#1

Temp.:

25.1 °C

Vapour pressure:

< 0 Pa

Vapour pressure 2

Key result

Test no.:

#2

Temp.:

25.1 °C

Vapour pressure:

< 0 Pa

Vapour pressure 3

Key result

Test no.:

#3

Temp.:

25.1 °C

Vapour pressure:

< 0 Pa

Any other information on results incl. tables

No test substance was detected in any of the condensation tubes indicating that the vapour pressure must be very low. The upper limit for the vapour pressure was determined by using the lowest check calibration concentration of 0.4032 µg. No substance peak could be detected. The vapour pressure must be less than 6.6 x 10-6 Pa at 25 °C.

Applicant's summary and conclusion

Conclusions:

The substance has a vapour pressure of less than 6.6 x 10-6 Pa at 25 °C.

Executive summary:

The vapour pressure of the substance was determined under GLP to OECD TG 104 using the gas saturation method. Saturator columns were prepared by filling them with glass beads that had been previously treated with the test substance dissolved in dichloromethane. Glass wool plugs were placed near the inlet and outlet of the columns, which were then conditioned and thermostated at the test temperature for a sufficient time to remove volatile impurities by passing through a supply of dry nitrogen. Subsequently, the gas flow was set by mass flow controllers and the gas passed was passed over the sample for an appropriate collection time. Two condensation tubes wee placed in a cooling trap at at temperature of 2.0 °C. The transported test substance was condensated at this temperature. Different flow rates were chosen at each test temperature, ranging from 18.32 to 35.72 mL/minute. After completion of the test, the condensation tubes were disconnected from the columns and the amount of transferred test item in each of the condensation tubes was determined by HPLC. The definite test was conducted at 25 °C. No test substance could be detected in any of the condensation tubes. The vapour pressure of the substance was determined to be less than 6.6 x 10-6 Pa at 25 °C under these conditions.