Registration Dossier
Registration Dossier
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EC number: 206-337-1 | CAS number: 328-84-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- June 12th, 1979 to July 17th, 1979
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Test material form:
- liquid
- Details on test material:
- Clear colourless liquid
- Specific details on test material used for the study:
- Purity not specified
Test animals
- Species:
- rat
- Strain:
- Wistar
- Remarks:
- Hoe WISKf(SPF71)
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: males: 160 g - 188 g (average 176.1 g)
- Fasting period before study: about 16 hours
- Housing: no data
- Diet: Altromin 1324 rat diet, ad libitum
- Water: tap water, ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod: no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: starch slime
- Remarks:
- starch content: 2%
- Details on oral exposure:
- concentration in vehicle: 25%
- Doses:
- 1250, 2000, 2500, 3150 and 5000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of weighing: weekly
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross pathology, histopathology - Statistics:
- Probit analyis according to Linder and Weber.
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 800 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 2 420 - <= 3 360
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 value for acute oral toxicity of the test substance is 2800 mg/kg bw in male Wistar rats.
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