Registration Dossier
Registration Dossier
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EC number: 201-741-4 | CAS number: 87-39-8
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Remarks:
- Prediction of in vivo skin sensitisation
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- OECD Toolbox Version 4.1. The toolbox is a software application to identify and fill (eco)toxicoligy data gaps for chemical hazard assesment. The toolbox is developed in cooperation with OECD and ECHA. Reference see www.qsartoolbox.org
Data source
Reference
- Reference Type:
- other: QSAR Toolbox prediction
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Guideline:
- other: REACH Guidande on QSARs R6. Read-across using OECD Toolbox version 4.1.
Test material
- Reference substance name:
- 5-hydroxyiminobarbituric acid
- EC Number:
- 201-741-4
- EC Name:
- 5-hydroxyiminobarbituric acid
- Cas Number:
- 87-39-8
- Molecular formula:
- C4H3N3O4
- IUPAC Name:
- 5-(hydroxyimino)-1,3-diazinane-2,4,6-trione
- Test material form:
- solid: particulate/powder
- Details on test material:
- Lot/batch No.: 201713807
Constituent 1
- Specific details on test material used for the study:
- SMILES: ON=C1C(=O)NC(=O)NC1=O
Results and discussion
In vivo (LLNA)
Results
- Remarks on result:
- other: QSAR prediction result
Any other information on results incl. tables
The OECD Toolbox V.4.1. made read-across from 1,3-Dimethyl-4-aminouracil CAS 6642-31-5, 5,5'-(1H-isoindole-1,3(2H)-diylidene)dibarbituric acid CAS 36888-99-0, Succinimide CAS 123-56-8, tetrahydrocyclopenta[c]pyrrole-1,3(2H,3aH)-dione CAS 5763-44-0, and Caffeine CAS 58-08-2 all of which were not considered as skin senstisers and predicted 5-hydroxyiminobarbituric acid to be negative for skin sensitisation.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Test substance is not a skin sensitizer based on OECD-toolbox prediction and read-across
- Executive summary:
The OECD Toolbox version 4.1. was used for prediction and read-across. Only the result in the applicability domain was accepted and the target substance 5-hydroxyiminobarbituric acid was predicted negative for skin sensitisation.
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