Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-182-7 | CAS number: 135-19-3
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The absence of specific toxicokinetics data from animal testing means that it is not possible to make firm conclusions concerning the absorption, distribution, metabolisation and excretion of 2-naphthol. However, there are several data sources available investigating the toxicity of the test substance or specific mechanisms relevant when assessing the toxicokinetics behaviour of a substance.
Physicochemical properties of the substance suggest that it is likely to be absorbed following an exposure via the oral, inhalation or dermal route, which is supported or confirmed by available experimental data.
2-naphthol is expected to be distributed in various compartment of the body, with higher concentrations identified in the lungs, kidneys and liver. Some effects identified during acute and repeated-dose toxicity studies suggest that the substance or its metabolites reached the central nervous system, which cannot be confirmed by available experimental data.
The urine is the main route of elimination of 2-naphthol, mainly in conjugated form – glucuronide and sulphate.
It is not considered justified to perform animal studies on this substance to further investigate its toxicokinetics behaviour.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
