Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 205-182-7 | CAS number: 135-19-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
Persistence
Not P and not vP based on: readily biodegradation.
In accordance with Annexes VII and VIII of REACH a ready biodegradability study was performed on the registered substance according to the OECD Testing Guideline 301A. This study concluded that the substance was readily biodegradable, with a degradation of 81% after 28 days (based on Dissolved Organic Carbon).
Since the substance is readily biodegradable, it does not meet the criteria to be P or vP.
Bioaccumulation
Not B and not vB based on: Log Kow is = 4.5.
The octanol:water partition coefficient of 2-naphthol was determined according to the OECD Testing Guideline 117 (HPLC Method). The Log Kow of the substance was concluded to range between 1.88 and 1.9.
Since the Log Kow is = 4.5, the substance does not meet the criteria to be B or vB criteria.
Toxicity
In accordance with Annexes VII and VIII of REACH no chronic toxicity testing to the aquatic environment was performed on the registered substance.
Short-term toxicity of 2-naphthol to aquatic invertebrates, algae, and fish was investigated. It was concluded that aquatic invertebrates (Gammarus minus) was the most sensitive species, with a 48h EC50 of 0.85 mg/L. Based on these results and in accordance with Regulation (EC) N° 1272/2008, 2-naphthol was classified as Aquatic Acute 1; H400 and Aquatic Chronic 3; H412. According to Table C.4-1 of ECHA Guidance on Information Requirements and Chemical Safety Assessment - Part C: PBT/vPvB assessment (Version 3.0 - June 2017), a substance shall not be considered as T (or potentially T) when the lowest EC50 is > 0.1.
Based on the available information on the registered substance it can be concluded that 2-naphthol does not meet the criteria for classification as mutagenic, toxic to reproduction, or toxic to specific organs following a repeated exposure according to Regulation (EC) N° 1272/2008. No data is available on the carcinogenicity of the substance and there is no requirement in Annexes VII and VIII of REACH to investigate this endpoint.
The substance does not meet the T criteria.
Conclusion
2-naphthol does not meet the PBT and the vPvB criteria. It is not considered relevant to further investigate the PBT or vPvB properties of the substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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