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Diss Factsheets
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EC number: 947-892-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Groups of mice were treated intraperitoneally. Mortality and physical condition were observed for 14 days following treatment.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Aluminum, hydroxy[29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32]-, chloro sulfo derivs., sodium salts
- EC Number:
- 307-259-1
- EC Name:
- Aluminum, hydroxy[29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32]-, chloro sulfo derivs., sodium salts
- Cas Number:
- 97592-62-6
- Molecular formula:
- not available
- IUPAC Name:
- Aluminum, hydroxy[29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32]-, chloro sulfo derivs., sodium salts
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- - Name as used in the study report: FAT 60'149/B
- Batch No.: Partie 1
Test animals
- Species:
- mouse
- Strain:
- other: Tif: MAG (SPF)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: raised on the premises
- Weight at study initiation: group averages 22-31 g
- Age at study initiation: 8 to 9 weeks
- Housing: In groups of 5 in Macrolon cages (type 2)
- Diet: ad libitum mouse food - NAFAG, Gossau SG
- Water: ad libitum
- Acclimation period: at least 4 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2
- Humidity (%): 55 ± 10
- Photoperiod (hrs dark / hrs light): 14 / 10
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: distilled water containing 2 % carboxymethylcellulose + 0.1 % Tween 80
- Details on exposure:
- Animals were treated intraperitoneally with a suspension of the substance in 10 mL/kg bw.
- Doses:
- 30, 100, 300, 1000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Animals were treated intraperitoneally. Physical condition and rate of deaths were monitored throughout the whole observation period.
- Statistics:
- LD50 including 95 % confidence limits are calculated by the logit model .
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 540 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 295 - <= 1 528
- Mortality:
- 4/5 male animals in the 1000 mg/kg dose group died on day 3 after treatment. 2/5 female animals in the 300 mg/kg dose group died on day 4 after treatment, 1/5 female animals in the 1000 mg/kg dose group died on day 2 after treatment and 3/5 on day 3 after treatment.
- Clinical signs:
- Clinical signs that were observed are severe sedation (day one of the treatment), slight to moderate dyspnoae, moderate ruffled fur, ventral, lateral and curved body position. No symptoms were observed in the surviving animals after day 7.
- Body weight:
- - 30 mg/kg bw: pre-test male/female 22/22 g, at day 7 male/female 29/27 g, at day 14 male/female 31/27 g.
- 100 mg/kg bw: pre-test male/female 30/26 g, at day 7 male/female 29/27 g, at day 14 male/female 33/28 g.
- 300 mg/kg bw: pre-test male/female 31/25 g, at day 7 male/female 31/26 g, at day 14 male/female 34/28 g.
- 1000 mg/kg bw: pre-test male/female 30/26 g, at day 7 male/female 29/24 g, at day 14 male/female 33/27 g. - Gross pathology:
- No substance related gross organ changes were seen.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.